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CXCR4 — ITCH

Pathways - manually collected, often from reviews:

• NCI Pathway Database CXCR4-mediated signaling events: ITCH (ITCH) → SDF1/CXCR4 complex (CXCL12-CXCR4) (modification, activates)
  Marchese et al., J Biol Chem 2001*
  Evidence: mutant phenotype, assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CXCR4 — ITCH (colocalization, biochemical) Malik et al., J Biol Chem 2012*
• IRef Biogrid Interaction: CXCR4 — ITCH (direct interaction, pull down) Bhandari et al., Mol Biol Cell 2009*
• IRef Biogrid Interaction: CXCR4 — ITCH (physical association, affinity chromatography technology) Bhandari et al., Mol Biol Cell 2009*
• IRef Biogrid Interaction: CXCR4 — ITCH (direct interaction, fluorescent resonance energy transfer) Bhandari et al., Mol Biol Cell 2009*

Text-mined interactions from Literome

Bhandari et al., J Biol Chem 2007 : Although it is known that AIP4 mediates ubiquitination and degradation of CXCR4 and that perturbations in these events contribute to disease, the mechanisms mediating AIP4 dependent regulation of CXCR4 degradation remain poorly understood
Malik et al., J Biol Chem 2012 : Here, we report a novel role for AIP4 and STAM-1 in regulation of CXCR4 signaling that is distinct from their function in CXCR4 trafficking