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IRS1 — YWHAE

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: INSR → Complex of IRS1-YWHAE (decreases, IRS1/YWHAE Activity)
  Evidence: both the insulin receptor and IRS proteins undergo serine phosphorylation, which may attenuate signalling by decreasing insulin-stimulated tyrosine phosphorylation19 and promote interaction with 14-3-3 proteins20.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: YWHAE — IRS1 Craparo et al., J Biol Chem 1997*
• IRef Bind_translation Interaction: YWHAE — IRS1 (two hybrid) Craparo et al., J Biol Chem 1997*
• IRef Bind_translation Interaction: YWHAE — IRS1 (competition binding) Craparo et al., J Biol Chem 1997*
• IRef Bind_translation Interaction: YWHAE — IRS1 (affinity chromatography technology) Craparo et al., J Biol Chem 1997*
• IRef Biogrid Interaction: YWHAE — IRS1 (direct interaction, pull down) Craparo et al., J Biol Chem 1997*
• IRef Biogrid Interaction: YWHAE — IRS1 (direct interaction, two hybrid) Craparo et al., J Biol Chem 1997*
• IRef Hprd Interaction: YWHAE — IRS1 (in vivo) Craparo et al., J Biol Chem 1997*, Ogihara et al., J Biol Chem 1997*
• IRef Intact Interaction: YWHAE — IRS1 (association, pull down) Ogihara et al., J Biol Chem 1997*
• IRef Intact Interaction: YWHAE — IRS1 (association, competition binding) Ogihara et al., J Biol Chem 1997*
• IRef Intact Interaction: YWHAE — IRS1 (physical association, two hybrid) Craparo et al., J Biol Chem 1997*
• IRef Intact Interaction: YWHAE — IRS1 (direct interaction, pull down) Craparo et al., J Biol Chem 1997*
• IRef Ophid Interaction: YWHAE — IRS1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: YWHAE — IRS1 (aggregation, confirmational text mining) Craparo et al., J Biol Chem 1997*