Gene interactions and pathways from curated databases and text-mining

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IRS1 — PDPK1

Pathways - manually collected, often from reviews:

  • WikiPathways Insulin Signaling: Complex of IRS1-PIK3CA → GSK3B/AKT2/AKT1/SGK3/SGK1/GSK3A/PDPK1/SGK2 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *