Gene interactions and pathways from curated databases and text-mining

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IRS1 — NOS1

Text-mined interactions from Literome

Sugita et al., J Biol Chem 2005 : Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells
Xu et al., Mol Endocrinol 2007 (Insulin Resistance...) : Recombinant CRP suppressed insulin induced NO production, inhibited the phosphorylation of Akt and endothelial nitric oxide synthase , and stimulated the phosphorylation of IRS-1 at the Ser307 site in a dose dependent manner