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IL12A — IRF8
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Masumi et al., FEBS Lett 2002
:
IRF-8/ICSBP and IRF-1 cooperatively
stimulate mouse
IL-12 promoter activity in macrophages ... We have previously shown that
IL-12p40 expression is impaired in ICSBP-deficient mice and that transfection of
ICSBP together with IRF-1 can
activate IL-12p40 expression in mouse macrophage cells ... Together, these results indicate that
ICSBP and IRF-1 cooperatively
stimulate murine
IL-12 transcription through a novel regulatory element in the murine promoter
Liu et al., J Exp Med 2003
:
Thus,
IRF-1 acts as a critical component of IFN-gamma signaling in the selective activation of
IL-12 p35 transcription in synergy with LPS mediated events
Lehtonen et al., Cytokine 2003
:
IFN-alpha and
IL-12 activate IFN regulatory factor 1 (IRF-1), IRF-4, and
IRF-8 gene expression in human NK and T cells ... Both IFN-alpha and
IL-12 strongly
up-regulated IRF-1,
IRF-4 , and IRF-8 mRNA and protein expression
Xiong et al., J Biol Chem 2005
:
Furthermore,
IRF-8 induced
IL-12 p40 synthesis in RAW264.7 cells was enhanced by dominant negative Cbl, and peritoneal macrophages from Cbl-/- mice showed increased IL-12 p40 protein production ... Furthermore,
IRF-8 induced
IL-12 p40 synthesis in RAW264.7 cells was enhanced by dominant negative Cbl, and peritoneal macrophages from Cbl-/- mice showed increased IL-12 p40 protein production
Kong et al., J Immunol 2007
:
Ectopic expression of Ro52 enhanced
IL-12p40 expression in IFN-gamma/TLR stimulated macrophages in an
IRF-8 dependent manner
la Sala et al., J Exp Med 2009
(Toxoplasmosis) :
Therefore, because
IRF8 is
essential for
IL-12 production and the differentiation of CD8alpha ( + ) cDCs and pDCs, these data suggest that CT and other Gs-protein agonists can affect IL-12 production and DC differentiation via a common mechanism involving IRF8