◀ Back to TLR4
IRF7 — TLR4
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
IRF7
→
TLR4
(indirect_complex)
Fitzgerald et al., J Exp Med 2003, Mori et al., J Biol Chem 2004, Hemmi et al., J Exp Med 2004, An et al., Immunity 2006, Lin et al., Mol Cell Biol 1998
-
Reactome Reaction:
IRF7
→
TLR4
(reaction)
Fitzgerald et al., Nat Immunol 2003, Fitzgerald et al., J Exp Med 2003, Mori et al., J Biol Chem 2004, Hemmi et al., J Exp Med 2004, An et al., Immunity 2006, Panne et al., J Biol Chem 2007, Lin et al., Mol Cell Biol 1998
Text-mined interactions from Literome
Sakaguchi et al., Biochem Biophys Res Commun 2003
:
We also provide evidence that the
LPS/TLR4 signaling
activates IRF-7 to induce IFN-beta, if IRF-7 is induced by IFNs prior to LPS simulation
Guiducci et al., J Exp Med 2008
:
PI3K is critical for the nuclear translocation of
IRF-7 and type I IFN production by human plasmacytoid predendritic cells in
response to
TLR activation
Abe et al., Arterioscler Thromb Vasc Biol 2008
(Inflammation...) :
Statins inhibited
TLR4 mediated
activation of
interferon ( IFN ) regulatory factor ( IRF)3 by either lipopolysaccharide (LPS) or palmitic acid, resulting in suppression of IFN-beta expression, but not that of NF-kappaB or JNK
Atzei et al., J Biol Chem 2010
:
We now describe the first functional characterization of the human ortholog of Cactin ( hCactin ) and show that it acts as a negative regulator of TLRs. Overexpression of hCactin suppresses
TLR induced
activation of NF-?B and
interferon-regulatory factor transcription factors and induction of TLR-responsive genes, whereas knockdown of endogenous hCactin augments TLR induction of these responses
Sisirak et al., Int J Cancer 2013
(Breast Neoplasms) :
Mechanisms of type I IFN inhibition did not involve
TLR downregulation but the
inhibition of
IRF-7 expression and nuclear translocation in pDC after their exposure to tumor derived supernatants or recombinant TGF-ß1 and TNF-a