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CHUK — IRF7

Pathways - manually collected, often from reviews:

• KEGG Toll-like receptor signaling pathway: CHUK → IRF7 (protein-protein, phosphorylation)
• KEGG Measles: CHUK → IRF7 (protein-protein, activation)
• WikiPathways Regulation of toll-like receptor signaling pathway: CHUK → IRF7 (activation)
• WikiPathways Toll-like Receptor Signaling Pathway: CHUK → IRF7 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of IRF7-CHUK (phosphorylation reaction, protein kinase assay) Pfaller et al., J Virol 2008*
• IRef Intact Interaction: CHUK — IRF7 (phosphorylation reaction, protein kinase assay) Pfaller et al., J Virol 2008*
• IRef Intact Interaction: Complex of IRF7-CHUK (phosphorylation reaction, protein kinase assay) Pfaller et al., J Virol 2008*

Text-mined interactions from Literome

Wang et al., Mol Immunol 2008 : It has been shown that the protein kinase I kappaB kinase alpha (IKK alpha) is critically involved in IRF7 activation and IFN-alpha production in Toll-like receptor 7/9 ( TLR7/9 ) signaling cascades
Gotoh et al., J Exp Med 2010 : Although activation of pDCs is triggered by engagement of nucleotide sensing toll-like receptors (TLR) 7 and 9, type I IFN induction additionally requires IkappaB kinase (IKK) alpha dependent activation of IFN regulatory factor (IRF) 7
Liang et al., Cell Res 2011 (Sarcoma, Kaposi) : Importantly, expression of miR-K12-11 attenuated IFN signaling by decreasing IKK? mediated IRF3/IRF7 phosphorylation and by inhibiting the activation of IKK? dependent IFN stimulating genes ( ISGs ), allowing miR-K12-11 suppression of antiviral immunity