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HIF1A — IRF6

Text-mined interactions from Literome

Frede et al., Biochem J 2006 (Anoxia) : Here we report that bacterial LPS ( lipopolysaccharide ) induces HIF-1alpha mRNA expression and HIF-1alpha protein accumulation in human monocytes as well as in non differentiated and differentiated cells of the human monocytic cell line THP-1 under normoxic conditions ... Whereas LPS increased HIF-1alpha mRNA expression through activation of a NF-kappaB ( nuclear factor kappaB ) site in the promoter of the HIF-1alpha gene, hypoxia post-translationally stabilized HIF-1alpha protein ... In cells pretreated with the p44/42 MAPK inhibitor PD 98059 or with RNAi ( interfering RNA ) directed against p44/42 MAPK, LPS induced HIF-1alpha accumulation and ADM expression were significantly decreased
Scharte et al., J Surg Res 2006 : LPS increases hepatic HIF-1alpha protein and expression of the HIF-1 dependent gene aldolase A in rats
Ramanathan et al., Mol Biol Cell 2007 : We examined whether LPS and/or NECA induce HIF-1alpha expression ... HIF-1alpha is transcriptionally induced by LPS and post-transcriptionally up-regulated in an A2AR dependent manner
Poulaki et al., FASEB J 2007 (Leukostasis...) : 17-AAG treatment significantly suppressed the LPS induced increase in retinal leukocyte adhesion ; vascular leakage ; NF-kappaB, HIF-1alpha , p38, and PI-3K activity ; and VEGF, TNF-alpha, and IL-1beta levels
Kim et al., Exp Cell Res 2007 (Bacterial Infections...) : However, the molecular mechanisms at the transcriptional level of HIF-1alpha induction by LPS remained undefined ... Here, we investigated the regulatory mechanism of HIF-1alpha expression by LPS in hepatocytes and identified that LPS induced HIF-1alpha mediate gene transcription of a typical inflammatory mediator, tumor-necrosis factor alpha (TNFalpha)
Oh et al., Neurosci Lett 2008 (Anoxia) : We then showed that LPS induced HIF-1alpha mRNA expression was blocked by an antioxidant, NADPH oxidase inhibitors, and siRNA of gp91phox, a subunit of NADPH oxidase ... In addition, we showed that specific pharmacological inhibitors of PI 3-kinase and protein kinase C decreased LPS induced HIF-1alpha mRNA expression ... Taken together, these results suggest that LPS induces HIF-1alpha mRNA expression and activation via NADPH oxidase and Sp1 in BV2 microglia
Mi et al., Cell cycle (Georgetown, Tex.) 2008 : Interestingly, LPS did not significantly affect HIF-1alpha protein levels or HIF-1 DNA binding activity relative to hypoxic induction ... Addition of ROS-scavengers completely abrogated the synergistic induction of HIF-1 transcriptional activity by LPS and hypoxia, but neither inhibited HIF-1 transcriptional activity induced by hypoxia alone nor affected HIF-1alpha protein levels or HIF-1 DNA binding induced by hypoxia alone or hypoxia plus LPS
Ramanathan et al., J Leukoc Biol 2009 : This switch involves transcriptional regulation of VEGF by HIF-1, transcriptional induction of HIF-1alpha by LPS ( TLR4 agonist ), and A ( 2A ) R-dependent post-transcriptional regulation of HIF-1alpha stability ... LPS induced expression of A ( 2A ) Rs and HIF-1alpha and A ( 2A ) R-dependent HIF-1alpha mRNA and protein stabilization provide mechanisms for the synergistic effects of LPS and A ( 2A ) R agonists on macrophage VEGF expression
Nicholas et al., Immunol Cell Biol 2010 : RNS and p38 MAP kinase ( known to contribute to LPS induced TLR4 dependent accumulation of HIF-1 alpha protein ) do not affect HIF-1 alpha prolyl hydroxylation
Labuzek et al., Naunyn Schmiedebergs Arch Pharmacol 2010 (Inflammation) : The observed alterations in the release or production of inflammatory mediators may be explained by the changes in NF-kappaB, HIF-1 alpha , and arginase I expression and 3- ( 4,5-dimethylthazol-2-yl ) -2,5-diphenyltetrazolinum bromide values in response to LPS , whereas the basis for the compound C effect on non stimulated microglia remains to be investigated