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IRF1 — STAT3
Pathways - manually collected, often from reviews:
-
FastForward regulation:
STAT3
→
IRF1
(transcriptional regulation, unknown)
Harroch et al., EMBO J 1994*, Saharinen et al., Blood 1997*
Evidence: DNABINDING
-
FastForward regulation:
STAT3
→
IRF1
(transcriptional regulation, unknown)
Matikainen et al., Blood 1999*, Galon et al., J Immunol 1999, Ruiz-Ruiz et al., J Biol Chem 2004*
Evidence: DNABINDING
-
FastForward regulation:
STAT3
→
IRF1
(transcriptional regulation, unknown)
Kotenko et al., J Immunol 2001*, Kotenko et al., EMBO J 1997*
Evidence: DNABINDING
-
FastForward regulation:
STAT3
→
IRF1
(transcriptional regulation, increase)
Li et al., J Biol Chem 1996
Evidence: DNABINDING
-
FastForward regulation:
STAT3, STAT1
→
IRF1
(transcriptional regulation, unknown)
Kotenko et al., J Immunol 2001*, Kotenko et al., EMBO J 1997*
Evidence: DNABINDING
-
NCI Pathway Database IL6-mediated signaling events:
STAT3 (dimer ) complex (STAT3)
→
IRF1 (IRF1)
(transcription, activates)
Harroch et al., J Biol Chem 1994*
Evidence: physical interaction
Text-mined interactions from Literome
Huang et al., J Clin Invest 2007
(Inflammation...) :
Enforced expression of STAT1,
IRF-1 , or GATA-1
enhanced phosphorylation of STAT1,
STAT3 , and STAT5 in cultured Gata1-deficient murine megakaryocytes, with concomitant megakaryocyte maturation
Yamanaka et al., EMBO J 1996
:
By using chimeric receptors consisting of the extracellular domain of growth hormone receptor and the transmembrane and cytoplasmic domain of gp130 with progressive C-terminal truncations, we showed that the membrane-proximal 133, but not 108, amino acids of gp130 could generate the signals for growth arrest, macrophage differentiation, down-regulation of c-myc and c-myb, induction of junB and
IRF1 and
Stat3 activation
Takeda et al., J Endocrinol 1998
:
The synergism was studied on the two other IL-6 response elements, the junB promoter ( JRE-IL-6 ) and the interferon regulatory factor-1 (IRF-1) promoter (
IRF-GAS ) which could be
activated by
STAT3