Gene interactions and pathways from curated databases and text-mining

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IRAK2 — TLR4

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Kobayashi et al., Cell 2002 (Salmonella Infections) : Thus, IRAK-M regulates TLR signaling and innate immune homeostasis
Hazeki et al., Eur J Immunol 2003 : PP2, an inhibitor of Src family tyrosine kinases, prevented the TLR induced phosphorylation of paxillin and Pyk2 without affecting TLR induced IRAK activation
Cuschieri et al., J Surg Res 2004 : LPS stimulation led to the mobilization of TLR4 to lipid rafts followed by phosphorylation and activation of IRAK , ERK 1/2, p38, and JNK/SAPK
Zhang et al., Infect Immun 2005 (Pseudomonas Infections) : We also determined that MyD88, IRAK , TRAF6, and Toll interacting protein (Tollip), but not TIRAP, were involved in the TLR mediated response to P. aeruginosa in HAECs
Keating et al., J Biol Chem 2007 : Thus we propose that IRAK-2 plays a more central role than IRAK-1 in TLR signaling to NFkappaB
Kawagoe et al., Nat Immunol 2008 : Thus, IRAK2 is critical in late-phase TLR responses , and IRAK1 and IRAK2 are essential for the initial responses to TLR stimulation
Uh et al., Reproductive biology and endocrinology : RB&E 2009 : Here we investigated the role of MyD88, TRIF and IRAK2 on cAMP induced CRH promoter activation in JEG3 cells in the absence of LPS/TLR4 stimulation
Flannery et al., J Biol Chem 2011 (MAP Kinase Signaling System) : Thus IRAK-2 in mice and humans may function differently, and therefore we analyzed the role of IRAK-2 in TLR responses in primary human cells ... siRNA knockdown of IRAK-2 expression in human peripheral blood mononuclear cells showed a role for human IRAK-2 in both TLR4- and TLR8 mediated early NF?B and p38 MAPK activation and in induction of TNF mRNA ... Collectively, these data demonstrate for the first time an essential role for IRAK-2 in primary human cells for both transcriptional and post-transcriptional TLR responses
Sandig et al., Eur J Immunol 2013 : We show that while IRAK2 is redundant for TLR4 signaling, IRAK1 is essential for TLR4 signaling in mast cells