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IQGAP1 — MAPK3
Pathways - manually collected, often from reviews:
-
NCI Pathway Database ErbB1 downstream signaling:
Erk1-2 (MAPK3/MAPK1)
→
IQGAP1 (IQGAP1)
(modification, collaborate)
Glading et al., J Biol Chem 2001*, Howe et al., Cell 1992, Roy et al., Mol Cell Biol 2005, Ren et al., Proc Natl Acad Sci U S A 2007, Minden et al., Science 1994, Zheng et al., J Biol Chem 1993, Huang et al., Proc Natl Acad Sci U S A 1993
Evidence: assay, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Roy et al., Mol Cell Biol 2005
(MAP Kinase Signaling System) :
Similarly,
ERK1 promoted MEK binding to
IQGAP1 , but either MEK protein altered the association between IQGAP1 and ERK
Casar et al., Mol Cell Biol 2009
:
To phosphorylate the EGFr,
ERK1/2 activated at lipid rafts require the participation of
IQGAP1