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AKT1 — INSR
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Insulin Pathway:
Insulin Receptor/Insulin/GRB14/PDK1 complex (INSR-INS-GRB14-PDPK1)
→
AKT1 (AKT1)
(modification, activates)
Egawa et al., J Biol Chem 2002, Cross et al., Nature 1995, Alessi et al., EMBO J 1996, Moule et al., J Biol Chem 1997, Cross et al., FEBS Lett 1997
-
NCI Pathway Database Signaling events mediated by PTP1B:
PTP1B/AKT1 complex (PTPN1-AKT1)
→
Insulin Receptor/Insulin complex (INSR-INS)
(modification, inhibits)
Elchebly et al., Science 1999*, Ravichandran et al., Mol Endocrinol 2001
Evidence: mutant phenotype, assay, physical interaction, other species
Text-mined interactions from Literome
Sadowski et al., Endocrinology 2001
:
We therefore tested the C2C12 myogenic cell line for its response to GH and demonstrate that C2C12 skeletal muscle cells rapidly respond to physiological levels of GH with increased tyrosine phosphorylation of the GH receptor, Janus kinase 2, signal transducer and activator of transcription-5a and -5b,
insulin receptor substrate-1, and
activation of MAPKs/ERKs and
protein kinase B/Akt ... We therefore tested the C2C12 myogenic cell line for its response to GH and demonstrate that C2C12 skeletal muscle cells rapidly respond to physiological levels of GH with increased tyrosine phosphorylation of the GH receptor, Janus kinase 2, signal transducer and activator of transcription-5a and -5b,
insulin receptor substrate-1, and
activation of MAPKs/ERKs and protein kinase
B/Akt
Pagliassotti et al., J Nutr 2003
:
Insulin receptor substrate (IRS) phosphorylation, IRS-association with phosphatidylinositol 3 (PI3)-kinase and
activation of
protein kinase B (PKB) were not significantly different among the refed groups
Bazuine et al., Biochem Biophys Res Commun 2005
:
We observed that pre-treatment with genistein did not affect insulin induced tyrosine kinase activity of the
insulin receptor or
activation of
protein kinase B
Klover et al., Endocrinology 2005
(Inflammation...) :
In a direct comparison of hepatic insulin signaling in Lep ( ob ) mice treated with anti-IL-6 vs. IgG treated controls, insulin dependent
insulin receptor autophosphorylation and
activation of
Akt ( pSer473 ) were increased by nearly 50 % with IL-6 depletion
Mehdi et al., Antioxid Redox Signal 2005
:
H2O2 induced phosphorylation of ERK1/2 and
PKB requires tyrosine kinase activity of
insulin receptor and c-Src
Treebak et al., Am J Physiol Cell Physiol 2009
:
In soleus from 129S6/sv mice,
insulin receptor substrate 1-associated phosphatidylinositol 3 (PI3)-kinase activity was markedly increased with A-769662, and
Akt phosphorylation and glucose uptake were
inhibited by wortmannin while phosphorylation of acetyl-CoA carboxylase ( S227 ) was unaffected
Jain et al., Mol Nutr Food Res 2010
(Diabetes Mellitus, Type 2...) :
While CDN and CP had no effect, activation of NFkappaB,
Akt and glucose transporter-2 levels were decreased,
insulin receptor substrate 1 (IRS-1) activation
increased in livers of CDNC-rats
Fox et al., Am J Physiol Endocrinol Metab 2011
(Diabetic Retinopathy) :
We showed previously that
insulin receptor signaling is diminished in retinas of animal models of diabetes and that downstream
Akt signaling is
involved in insulin mediated retinal neuronal survival
Fox et al., Cancer Res 2011
(Adenocarcinoma...) :
Inhibition of
InsR and IGF-IR with the dual tyrosine kinase inhibitor OSI-906 prevented the emergence of hormone independent cells and tumors in vivo,
inhibited parental and LTED cell growth and
PI3K/AKT signaling, and suppressed growth of established MCF-7 xenografts in ovariectomized mice, whereas treatment with the neutralizing IGF-IR monoclonal antibody MAB391 was ineffective
He et al., Ann Oncol 2012
(Breast Neoplasms...) :
Human epidermal growth factor receptor ( HER2 ),
insulin receptor and IGF-I receptor
involve the same
PI3K/AKT/mTOR signaling, and different antidiabetic pharmacotherapy may differentially affect this pathway, leading to different prognoses of HER2+ breast cancer
González-RodrĂguez et al., Aging Cell 2012
(Anoxia...) :
Conversely,
insulin receptor mediated
Akt/Foxo1 signaling was attenuated in these aged control mice
Kohn et al., EMBO J 1995
:
These results indicate that
RAC-PK alpha activity can be
regulated by the
insulin receptor