Gene interactions and pathways from curated databases and text-mining

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AKT1 — INSR

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Sadowski et al., Endocrinology 2001 : We therefore tested the C2C12 myogenic cell line for its response to GH and demonstrate that C2C12 skeletal muscle cells rapidly respond to physiological levels of GH with increased tyrosine phosphorylation of the GH receptor, Janus kinase 2, signal transducer and activator of transcription-5a and -5b, insulin receptor substrate-1, and activation of MAPKs/ERKs and protein kinase B/Akt ... We therefore tested the C2C12 myogenic cell line for its response to GH and demonstrate that C2C12 skeletal muscle cells rapidly respond to physiological levels of GH with increased tyrosine phosphorylation of the GH receptor, Janus kinase 2, signal transducer and activator of transcription-5a and -5b, insulin receptor substrate-1, and activation of MAPKs/ERKs and protein kinase B/Akt
Pagliassotti et al., J Nutr 2003 : Insulin receptor substrate (IRS) phosphorylation, IRS-association with phosphatidylinositol 3 (PI3)-kinase and activation of protein kinase B (PKB) were not significantly different among the refed groups
Bazuine et al., Biochem Biophys Res Commun 2005 : We observed that pre-treatment with genistein did not affect insulin induced tyrosine kinase activity of the insulin receptor or activation of protein kinase B
Klover et al., Endocrinology 2005 (Inflammation...) : In a direct comparison of hepatic insulin signaling in Lep ( ob ) mice treated with anti-IL-6 vs. IgG treated controls, insulin dependent insulin receptor autophosphorylation and activation of Akt ( pSer473 ) were increased by nearly 50 % with IL-6 depletion
Mehdi et al., Antioxid Redox Signal 2005 : H2O2 induced phosphorylation of ERK1/2 and PKB requires tyrosine kinase activity of insulin receptor and c-Src
Treebak et al., Am J Physiol Cell Physiol 2009 : In soleus from 129S6/sv mice, insulin receptor substrate 1-associated phosphatidylinositol 3 (PI3)-kinase activity was markedly increased with A-769662, and Akt phosphorylation and glucose uptake were inhibited by wortmannin while phosphorylation of acetyl-CoA carboxylase ( S227 ) was unaffected
Jain et al., Mol Nutr Food Res 2010 (Diabetes Mellitus, Type 2...) : While CDN and CP had no effect, activation of NFkappaB, Akt and glucose transporter-2 levels were decreased, insulin receptor substrate 1 (IRS-1) activation increased in livers of CDNC-rats
Fox et al., Am J Physiol Endocrinol Metab 2011 (Diabetic Retinopathy) : We showed previously that insulin receptor signaling is diminished in retinas of animal models of diabetes and that downstream Akt signaling is involved in insulin mediated retinal neuronal survival
Fox et al., Cancer Res 2011 (Adenocarcinoma...) : Inhibition of InsR and IGF-IR with the dual tyrosine kinase inhibitor OSI-906 prevented the emergence of hormone independent cells and tumors in vivo, inhibited parental and LTED cell growth and PI3K/AKT signaling, and suppressed growth of established MCF-7 xenografts in ovariectomized mice, whereas treatment with the neutralizing IGF-IR monoclonal antibody MAB391 was ineffective
He et al., Ann Oncol 2012 (Breast Neoplasms...) : Human epidermal growth factor receptor ( HER2 ), insulin receptor and IGF-I receptor involve the same PI3K/AKT/mTOR signaling, and different antidiabetic pharmacotherapy may differentially affect this pathway, leading to different prognoses of HER2+ breast cancer
González-Rodríguez et al., Aging Cell 2012 (Anoxia...) : Conversely, insulin receptor mediated Akt/Foxo1 signaling was attenuated in these aged control mice
Kohn et al., EMBO J 1995 : These results indicate that RAC-PK alpha activity can be regulated by the insulin receptor