Gene interactions and pathways from curated databases and text-mining

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ILK — MAPK3

Text-mined interactions from Literome

Leung-Hagesteijn et al., Mol Cell Biol 2005 : To investigate the role of ILK in BMP7 signaling, we showed that ILK overexpression increased basal and BMP7 induced levels of phospho-p38 ( MAPK ) and phospho-ATF-2 ... Consistent with its inhibitory effects on IMCD-3 cell morphogenesis, expression of ILK ( E359K ) blocked BMP7 dependent increases in phospho-p38 ( MAPK ) and phospho-ATF-2
Sawai et al., Oncogene 2006 (Disease Progression...) : Overexpressed ILK enhances the IL-1alpha induced p38 MAPK phosphorylation more strongly through glycogen synthase kinase 3 ( GSK-3 ) activation, and subsequently induces AP-1 activation, which promotes aggressive capabilities of pancreatic cancer cells
Huang et al., Biochem J 2006 : The results demonstrate reciprocal inhibition between two pathways downstream of PI3K, with ILK inhibiting PAK1, and p38 MAPK inhibiting ILK
Ruiz-Torres et al., Cell Physiol Biochem 2006 : ILK overexpression reduced ERK 1/2 phosphorylation and this could promote the reduction in P-selectin and the increase in MCP-1 ... Collagen I decreased ILK activity and this would induce an increase in ERK 1/2 activity in HuVEC
Zhang et al., Hepatology 2006 (Disease Progression...) : Our studies also showed that ILK is involved in the phosphorylation of ERK 1/2, p38 MAPK , JNK, and PKB and that selective inhibition of ILK expression by siRNA results in a significant decrease in their phosphorylation ... Our studies also showed that ILK is involved in the phosphorylation of ERK 1/2 , p38 MAPK, JNK, and PKB and that selective inhibition of ILK expression by siRNA results in a significant decrease in their phosphorylation
Liu et al., Clin Chim Acta 2007 : Chemical inhibitors were used to assess the role of MEK/ERK1/2, PI3-K, and P38 MAPK signaling pathways in induction of ILK by CTGF
Wu et al., Am J Nephrol 2010 : LXA ( 4 ) inhibited the expression and activity of ILK and activation of Ras, ERK1/2 , PI3-K and Akt in HK-2 cells stimulated by CTGF
Yang et al., J Trauma Acute Care Surg 2013 (Disease Models, Animal...) : AngII increased the activity of protein kinase C-dependent phosphatase inhibitor of 17-kD ( CPI17 ), integrin linked kinase (ILK), and zipper interacting protein kinase (ZIPK), The effect of AngII on CPI17 was blocked by ERK and p38 MAPK inhibitor, while the effect of AngII on ILK and ZIPK was only blocked by ERK inhibitor