Gene interactions and pathways from curated databases and text-mining

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IL12A — IL8

Text-mined interactions from Literome

Willermain et al., Invest Ophthalmol Vis Sci 2000 : Although interferongamma enhanced IL-6 and IL-8 production, CD40 triggering of IFNgamma activated hRPE cells did not induce IL-12 secretion
Ethuin et al., J Leukoc Biol 2001 : Because IL-8 is a strong chemokine for polymorphonuclear neutrophils ( PMNs ), we investigated the effect of IL-12 on PMN IL-8 production
Al-Mohanna et al., J Leukoc Biol 2002 : IL-12 dependent nuclear factor-kappaB activation leads to de novo synthesis and release of IL-8 and TNF-alpha in human neutrophils ... In addition IL-12 induces the de novo synthesis and production of IL-8 and tumor necrosis factor alpha (TNF-alpha) in a calcium- and ROM dependent manner
Hessle et al., Inflammation 2003 (Inflammation) : We have seen that Gram-positives preferentially induce IL-12 and TNF-alpha, whereas Gram-negatives induce more IL-10, IL-6, and IL-8
EnrĂ­quez-de-Salamanca et al., Cytokine 2008 (Conjunctivitis, Allergic...) : TNF-alpha stimulated secretion of IL-12p40 was significantly increased by 30 min ; GM-CSF, MCP-1, IL-6, IL-7, IL-8 , and RANTES were significantly increased by 2 h, and IFN-gamma and IL-1alpha by 24 h
Martner et al., Infect Immun 2009 : If pneumococcal LytA was inactivated by mutation or by culture in a medium containing excess choline, the pneumococci induced production of significantly more TNF, IFN-gamma, and IL-12 in PBMC, whereas the production of IL-6, IL-8 , and IL-10 was unaffected ... Further, adding autolyzed pneumococci to intact bacteria inhibited production of TNF, IFN-gamma, and IL-12 in a dose dependent manner but did not inhibit production of IL-6, IL-8 , and IL-10 in response to the intact bacteria
Hegde et al., Cell Immunol 1995 (Neoplasms, Experimental) : AK-5 tumor induced expression of interleukin-12 : role of IL-12 in NK-mediated AK-5 regression
Hedges et al., Cytokine 1996 : IL-5, IL-12 , IL-13 and TGF-beta 1 additively enhanced the bacterially induced IL-6 secretion, but they did not affect IL-8 secretion