Gene interactions and pathways from curated databases and text-mining

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HIF1A — IL8

Text-mined interactions from Literome

Colla et al., Blood 2007 (Multiple Myeloma...) : In turn, we show that the inhibition of HIF-1alpha by siRNA suppressed IL-8 and OPN production by MM cells under hypoxia
Cane et al., Cell Microbiol 2010 : HIF-1alpha mediates the induction of IL-8 and VEGF expression on infection with Afa/Dr diffusely adhering E. coli and promotes EMT-like behaviour ... Using RNA interference we show that bacteria induced HIF-1alpha regulates the expression of IL-8 , VEGF and Twist1, thereby pointing to a role for HIF-1 in angiogenesis and inflammation