Gene interactions and pathways from curated databases and text-mining

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CXCR4 — IL8

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Suetomi et al., J Biol Chem 1999 : This study demonstrates that IL-8 recognizes and activates CXCR1, CXCR2 , and the Duffy antigen by distinct mechanisms
Ping et al., J Neurooncol 2007 (Brain Neoplasms...) : The anti-cancer compound Nordy inhibits CXCR4 mediated production of IL-8 and VEGF by malignant human glioma cells
Ping et al., Zhonghua Bing Li Xue Za Zhi 2007 (Brain Neoplasms...) : Activation of CXCR4 on glioma stem cells induced calcium mobilization and increased VEGF and IL-8 protein secretion
Li et al., Oral Oncol 2012 (Carcinoma, Squamous Cell...) : The angiogenesis profiling from angiogenesis array and reverse transcription polymerase chain reaction indicates that IL-8 can be significantly triggered by SDF-1/CXCR4 interaction in LHSCCs