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CXCR4 — IL8
Pathways - manually collected, often from reviews:
-
KEGG Chemokine signaling pathway:
CCL1/CCL11/CCL13/CCL14/CCL15/CCL16/CCL17/CCL18/CCL19/CCL2/CCL20/CCL21/CCL22/CCL23/CCL24/CCL25/CCL26/CCL27/CCL28/CCL3/CCL3L1/CCL3L3/CCL4/CCL4L1/CCL4L2/CCL5/CCL7/CCL8/CX3CL1/CXCL1/CXCL10/CXCL11/CXCL12/CXCL13/CXCL14/CXCL16/CXCL2/CXCL3/CXCL5/CXCL6/CXCL9/IL8/PF4/PF4V1/PPBP/XCL1/XCL2
→
CCR1/CCR10/CCR2/CCR3/CCR4/CCR5/CCR6/CCR7/CCR8/CCR9/CX3CR1/CXCR1/CXCR2/CXCR3/CXCR4/CXCR5/CXCR6/XCR1
(protein-protein, activation)
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Reactome Reaction:
IL8
→
CXCR4
(reaction)
Lambert et al., Science signaling 2008, Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, Takami et al., Brain Res Mol Brain Res 1994
Text-mined interactions from Literome
Suetomi et al., J Biol Chem 1999
:
This study demonstrates that
IL-8 recognizes and
activates CXCR1,
CXCR2 , and the Duffy antigen by distinct mechanisms
Ping et al., J Neurooncol 2007
(Brain Neoplasms...) :
The anti-cancer compound Nordy inhibits
CXCR4 mediated production of
IL-8 and VEGF by malignant human glioma cells
Ping et al., Zhonghua Bing Li Xue Za Zhi 2007
(Brain Neoplasms...) :
Activation of
CXCR4 on glioma stem cells induced calcium mobilization and
increased VEGF and
IL-8 protein secretion
Li et al., Oral Oncol 2012
(Carcinoma, Squamous Cell...) :
The angiogenesis profiling from angiogenesis array and reverse transcription polymerase chain reaction indicates that
IL-8 can be significantly
triggered by
SDF-1/CXCR4 interaction in LHSCCs