◀ Back to STAT3
IL6ST — STAT3
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
STAT3
→
IL6ST
(increases)
Gao et al., J Clin Invest 2007*
Evidence: To determine whether paracrine production of IL-6 was responsible for activating the gp130 receptor in these cell lines, conditioned medium (CM) was isolated from 11-18 cells and applied to MCF-10A cells (which do not express pSTAT3) in the absence or presence of various blocking antibodies against gp130, IL-6, IL-6–specific receptor IL-6R, and other gp130 pathway cytokines, OSM and LIF. 11-18 CM induced high levels of pSTAT3, which was inhibited by gp130, IL-6 ligand, or IL-6 receptor antibod...
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OpenBEL Selventa BEL large corpus:
STAT3
→
IL6ST
(increases)
Gao et al., J Clin Invest 2007*
Evidence: Treatment with anti-gp130 antibody (B-R3) or anti–IL-6 antibody inhibited pSTAT3 in 11-18, H1650, and H3255 cells (Figure 4A).
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NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
STAT3 (dimer ) complex (STAT3)
(modification, activates)
Sonnenblick et al., Mol Cell Biol 2004, Chung et al., Science 1997
Evidence: mutant phenotype, reporter gene, physical interaction, other species
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NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
STAT3 (dimer)/PIAS3 complex (STAT3-PIAS3)
(modification, activates)
Sonnenblick et al., Mol Cell Biol 2004, Chung et al., Science 1997
Evidence: mutant phenotype, reporter gene, physical interaction, other species
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NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
STAT3 (dimer ) complex (STAT3)
(modification, activates)
Kortylewski et al., J Biol Chem 2003
Evidence: physical interaction
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NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
STAT3 (dimer)/FOXO1 complex (STAT3-FOXO1)
(modification, activates)
Kortylewski et al., J Biol Chem 2003
Evidence: physical interaction
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NCI Pathway Database IL27-mediated signaling events:
STAT3 (STAT3)
→
IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3)
(modification, collaborate)
Lucas et al., Proc Natl Acad Sci U S A 2003
Evidence: mutant phenotype, other species
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NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
STAT3 (STAT3)
(modification, activates)
Jain et al., J Biol Chem 1999, Schuringa et al., J Biol Chem 2001, Novotny-Diermayr et al., J Biol Chem 2002, Croker et al., Nat Immunol 2003, Lang et al., Nat Immunol 2003, Yasukawa et al., Nat Immunol 2003, Novotny-Diermayr et al., J Biol Chem 2005, Guschin et al., EMBO J 1995, Wegenka et al., Mol Cell Biol 1993, Zhong et al., Science 1994, Wegenka et al., Mol Cell Biol 1994, Lütticken et al., Science 1994, Kaptein et al., J Biol Chem 1996, Gerhartz et al., J Biol Chem 1996, Haan et al., J Biol Chem 1999
Evidence: mutant phenotype, assay, physical interaction, other species
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Reactome Reaction:
IL6ST
→
STAT3
(indirect_complex)
Decker et al., Oncogene 2000*, Gerhartz et al., J Biol Chem 1996, Hemmann et al., J Biol Chem 1996
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Reactome Reaction:
IL6ST
→
STAT3
(reaction)
Zhong et al., Science 1994, Gerhartz et al., J Biol Chem 1996, Hemmann et al., J Biol Chem 1996
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WikiPathways MicroRNAs in cardiomyocyte hypertrophy:
IL6ST
→
STAT3
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Bind_translation Interaction:
IL6ST
—
STAT3
(coimmunoprecipitation)
Novotny-Diermayr et al., J Biol Chem 2002
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IRef Bind_translation Interaction:
IL6ST
—
STAT3
(affinity chromatography technology)
Novotny-Diermayr et al., J Biol Chem 2002
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IRef Biogrid Interaction:
STAT3
—
IL6ST
(physical association, affinity chromatography technology)
Novotny-Diermayr et al., J Biol Chem 2002
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MIPS CORUM IL6ST-PRKCD-STAT3 complex:
IL6ST-PRKCD-STAT3 complex complex (IL6ST-PRKCD-STAT3)
Novotny-Diermayr et al., J Biol Chem 2002
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IRef Corum Interaction:
Complex of PRKCD-STAT3-IL6ST
(association, coimmunoprecipitation)
Novotny-Diermayr et al., J Biol Chem 2002
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IRef Hprd Interaction:
STAT3
—
IL6ST
(in vivo)
Novotny-Diermayr et al., J Biol Chem 2002
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IRef Ophid Interaction:
IL6ST
—
STAT3
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Shirogane et al., Immunity 1999
:
The
activation of
STAT3 by the cytokine receptor
gp130 is required for both the G1 to S cell cycle transition and antiapoptosis
Nishinakamura et al., Dev Biol 1999
:
Activation of
Stat3 by cytokine receptor
gp130 ventralizes Xenopus embryos independent of BMP-4
Ohtani et al., Immunity 2000
(Acute-Phase Reaction...) :
The gp130F759/F759 mice showed prolonged
gp130 induced
STAT3 activation, indicating a negative regulatory role for SHP2
Sun et al., Biochem Biophys Res Commun 2002
:
Stimulation of
gp130 on hippocampal neurons
resulted in tyrosine phosphorylation of
STAT3 and activation of p42 and p44 MAP kinases
Takizawa et al., Exp Hematol 2003
:
In particular, the
activation of
STAT3 by
gp130 is found to be important in this process
Ozawa et al., Mol Cell Neurosci 2004
:
We demonstrated that
STAT3 activation, but not SHP2 activation, is
responsible for the
CNTF/gp130 signaling that inhibits expression of Rhodopsin and its upstream activator, crx, in the retinal explants derived from P0 mice ( P0 retinal explants ), utilizing STAT3-deficient retina and electroporation of dominant negative form of STAT3 ( STAT3F )
Rhee et al., J Neurosci 2004
:
Inhibition of the cytokine receptor gp130 using neutralizing antibodies reveals that
gp130 is
required for both CNTF induced
STAT3 and ERK phosphorylation
Jenkins et al., Nat Med 2005
(Adenoma...) :
The latent transcription factor
Stat3 is
activated by
gp130 , the common receptor for the interleukin (IL)-6 cytokine family and other growth factor and cytokine receptors
Oberg et al., Int Immunol 2006
:
Differential expression of CD126 and
CD130 mediates different
STAT-3 phosphorylation in CD4+CD25- and CD25high regulatory T cells
Mitsuyama et al., Gut 2006
(Disease Models, Animal...) :
We also examined the
effects of intravenously injected hyper-IL-6, an IL-6/soluble IL-6 receptor fusion protein, and of soluble
gp130-Fc , a specific inhibitor of soluble IL-6 receptor signalling, on
STAT3 phosphorylation and disease severity in SAMP1/Yit mice
Punjabi et al., J Virol 2007
(Herpesviridae Infections...) :
KSHV upregulates gp130 receptor expression, and both
gp130 and JAK2 are
required for the activation of
STAT3
Ehlting et al., J Immunol 2007
(MAP Kinase Signaling System) :
The potential of some proinflammatory mediators to inhibit
gp130 dependent
STAT3 activation by enhancing suppressor of cytokine signaling (SOCS) 3 expression represents an important molecular mechanism admitting the modulation of the cellular response toward gp130 mediated signals
Sanz et al., Glia 2008
:
The binding of IL-6 to its receptor (IL6R) triggers
gp130 mediated
activation of STAT1 and
STAT3 as well as SHP2 phosphatase and ERK1/2
Zhu et al., J Invest Dermatol 2008
:
We addressed this question genetically by deleting the suppressor of cytokine signaling (SOCS)3, a negative regulator of
gp130 mediated
STAT3 activation
Dierssen et al., J Biol Chem 2008
(Acute-Phase Reaction...) :
In summary,
gp130 dependent
STAT3 activation and concomitant SOCS3 during liver regeneration is involved in timing of DNA synthesis and protects hepatocyte proliferation during stress conditions
Snyder et al., J Biol Chem 2010
:
In
response to
gp130 receptor activation,
Stat3 becomes phosphorylated by the receptor associated Janus kinase, forms dimers, and enters the nucleus where it binds to Stat3 target genes and regulates their expression
Traum et al., J Leukoc Biol 2012
:
However, BMMC stimulation with IL-10 and consequential
STAT3 activation
increased gp130 expression, which resulted in a functional
gp130 receptor on the BMMC cell surface
Couto et al., Proc Natl Acad Sci U S A 2012
(Carcinoma, Papillary...) :
Using human thyroid cancer derived cell lines [ harboring rearranged during transfection (RET)/PTC, v-RAF murine sarcoma viral oncogene homolog B ( BRAF ), or rat sarcoma virus oncogene ( RAS ) alterations ], we determined that
IL-6/gp130/JAK signaling is
responsible for
STAT3 activation
Ponce et al., Biochim Biophys Acta 2013
(Chagas Disease) :
Interleukin-6 mediates host defense and cell survival mainly through the
activation of the transcription factor
STAT3 via the glycoprotein
gp130 , a shared signal transducing receptor for several IL-6-type cytokines
Lai et al., J Biol Chem 1995
:
However,
gp130 preferentially
activated STAT1 and
STAT3
Nakashima et al., FEBS Lett 1997
:
Stimulation of either a long form of OB-R or
gp130 led to tyrosine phosphorylation of
STAT3 , whereas stimulation of the truncated form of OB-R that is predominantly expressed in dbldb mice failed to do so