Gene interactions and pathways from curated databases and text-mining

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IL6ST — STAT3

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Shirogane et al., Immunity 1999 : The activation of STAT3 by the cytokine receptor gp130 is required for both the G1 to S cell cycle transition and antiapoptosis
Nishinakamura et al., Dev Biol 1999 : Activation of Stat3 by cytokine receptor gp130 ventralizes Xenopus embryos independent of BMP-4
Ohtani et al., Immunity 2000 (Acute-Phase Reaction...) : The gp130F759/F759 mice showed prolonged gp130 induced STAT3 activation, indicating a negative regulatory role for SHP2
Sun et al., Biochem Biophys Res Commun 2002 : Stimulation of gp130 on hippocampal neurons resulted in tyrosine phosphorylation of STAT3 and activation of p42 and p44 MAP kinases
Takizawa et al., Exp Hematol 2003 : In particular, the activation of STAT3 by gp130 is found to be important in this process
Ozawa et al., Mol Cell Neurosci 2004 : We demonstrated that STAT3 activation, but not SHP2 activation, is responsible for the CNTF/gp130 signaling that inhibits expression of Rhodopsin and its upstream activator, crx, in the retinal explants derived from P0 mice ( P0 retinal explants ), utilizing STAT3-deficient retina and electroporation of dominant negative form of STAT3 ( STAT3F )
Rhee et al., J Neurosci 2004 : Inhibition of the cytokine receptor gp130 using neutralizing antibodies reveals that gp130 is required for both CNTF induced STAT3 and ERK phosphorylation
Jenkins et al., Nat Med 2005 (Adenoma...) : The latent transcription factor Stat3 is activated by gp130 , the common receptor for the interleukin (IL)-6 cytokine family and other growth factor and cytokine receptors
Oberg et al., Int Immunol 2006 : Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4+CD25- and CD25high regulatory T cells
Mitsuyama et al., Gut 2006 (Disease Models, Animal...) : We also examined the effects of intravenously injected hyper-IL-6, an IL-6/soluble IL-6 receptor fusion protein, and of soluble gp130-Fc , a specific inhibitor of soluble IL-6 receptor signalling, on STAT3 phosphorylation and disease severity in SAMP1/Yit mice
Punjabi et al., J Virol 2007 (Herpesviridae Infections...) : KSHV upregulates gp130 receptor expression, and both gp130 and JAK2 are required for the activation of STAT3
Ehlting et al., J Immunol 2007 (MAP Kinase Signaling System) : The potential of some proinflammatory mediators to inhibit gp130 dependent STAT3 activation by enhancing suppressor of cytokine signaling (SOCS) 3 expression represents an important molecular mechanism admitting the modulation of the cellular response toward gp130 mediated signals
Sanz et al., Glia 2008 : The binding of IL-6 to its receptor (IL6R) triggers gp130 mediated activation of STAT1 and STAT3 as well as SHP2 phosphatase and ERK1/2
Zhu et al., J Invest Dermatol 2008 : We addressed this question genetically by deleting the suppressor of cytokine signaling (SOCS)3, a negative regulator of gp130 mediated STAT3 activation
Dierssen et al., J Biol Chem 2008 (Acute-Phase Reaction...) : In summary, gp130 dependent STAT3 activation and concomitant SOCS3 during liver regeneration is involved in timing of DNA synthesis and protects hepatocyte proliferation during stress conditions
Snyder et al., J Biol Chem 2010 : In response to gp130 receptor activation, Stat3 becomes phosphorylated by the receptor associated Janus kinase, forms dimers, and enters the nucleus where it binds to Stat3 target genes and regulates their expression
Traum et al., J Leukoc Biol 2012 : However, BMMC stimulation with IL-10 and consequential STAT3 activation increased gp130 expression, which resulted in a functional gp130 receptor on the BMMC cell surface
Couto et al., Proc Natl Acad Sci U S A 2012 (Carcinoma, Papillary...) : Using human thyroid cancer derived cell lines [ harboring rearranged during transfection (RET)/PTC, v-RAF murine sarcoma viral oncogene homolog B ( BRAF ), or rat sarcoma virus oncogene ( RAS ) alterations ], we determined that IL-6/gp130/JAK signaling is responsible for STAT3 activation
Ponce et al., Biochim Biophys Acta 2013 (Chagas Disease) : Interleukin-6 mediates host defense and cell survival mainly through the activation of the transcription factor STAT3 via the glycoprotein gp130 , a shared signal transducing receptor for several IL-6-type cytokines
Lai et al., J Biol Chem 1995 : However, gp130 preferentially activated STAT1 and STAT3
Nakashima et al., FEBS Lett 1997 : Stimulation of either a long form of OB-R or gp130 led to tyrosine phosphorylation of STAT3 , whereas stimulation of the truncated form of OB-R that is predominantly expressed in dbldb mice failed to do so