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IL6ST — MAPK6

Text-mined interactions from Literome

Chen et al., J Virol 2006 : Human herpesvirus 8 interleukin-6 ( vIL-6 ) displays 25 % amino acid identity with human IL-6 ( hIL-6 ) and shares an overall four-helix-bundle structure and gp130 mediated STAT/mitogen activated protein kinase signaling with its cellular counterpart
Schiemann et al., J Biol Chem 1997 : Our results demonstrate that gp130 and LIFR stimulate MAPK activity through box 3-independent mechanisms involving : ( i ) effects at Tyr-118 and Tyr-115, respectively, for maximal stimulation of MAPK activity and ( ii ) a Jak/Tyk dependent pathway that, together with Tyr-118- or Tyr-115 generated signals, converges at the level of Ras during activation of MAPK by cytokine