Gene interactions and pathways from curated databases and text-mining

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IL6ST — MAPK3

Text-mined interactions from Literome

Oberg et al., Int Immunol 2006 : Interestingly, we observed a correlation between CD126 and CD130 expression with STAT-3 phosphorylation in CD4+CD25- T cells compared with Tregs after stimulation with IL-6 or H-IL-6, whereas the MAPK extracellular signal regulated kinase 1/2 were not activated by CD130 dimerization
Chen et al., J Virol 2006 : Human herpesvirus 8 interleukin-6 ( vIL-6 ) displays 25 % amino acid identity with human IL-6 ( hIL-6 ) and shares an overall four-helix-bundle structure and gp130 mediated STAT/mitogen activated protein kinase signaling with its cellular counterpart
Fahmi et al., Cell Signal 2013 (Hypertrophy...) : p42/p44-MAPK and PI3K are sufficient for IL-6 family cytokines/gp130 to signal to hypertrophy and survival in cardiomyocytes in the absence of JAK/STAT activation
Schiemann et al., J Biol Chem 1997 : Our results demonstrate that gp130 and LIFR stimulate MAPK activity through box 3-independent mechanisms involving : ( i ) effects at Tyr-118 and Tyr-115, respectively, for maximal stimulation of MAPK activity and ( ii ) a Jak/Tyk dependent pathway that, together with Tyr-118- or Tyr-115 generated signals, converges at the level of Ras during activation of MAPK by cytokine