Gene interactions and pathways from curated databases and text-mining

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IGF2 — IL6

Text-mined interactions from Literome

Kwon et al., Biochem Biophys Res Commun 2000 (Psoriasis) : Insulin-like growth factor II induces interleukin-6 expression via NFkappaB activation in psoriasis ... We found that IGF-II induced the IL-6 mRNA expression significantly ... Interestingly, IL-6 promoter activity and the binding activity of NFkappaB were remarkably increased by IGF-II
Tu et al., Cancer Res 2000 (MAP Kinase Signaling System...) : In correlation with activation of PI 3-K, IGF-I also effectively activated the AKT kinase in 8226 and OCI-My5 cells, and IL-6 activated AKT in AF-10 and MH.60 cells
Anwar et al., Circulation 2002 (Arteriosclerosis) : IL-1beta, IL-6 , and IFN-gamma did not regulate IGF-1, IGF-1 receptor (R), or IGF binding proteins ( IGFBPs )
Perrier d'Hauterive et al., Journal de gynécologie, obstétrique et biologie de la reproduction 2004 : The molecular basis of the implantation window remains to be defined In the present study, we investigated the role of hCG, TGFbeta1, IGF1 and IGF2 in the secretion of leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) by human epithelial endometrial cells in culture ... The molecular basis of the implantation window remains to be defined In the present study, we investigated the role of hCG, TGFbeta1, IGF1 and IGF2 in the secretion of leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) by human epithelial endometrial cells in culture
Nemet et al., Am J Physiol Regul Integr Comp Physiol 2006 : The results suggest that IL-6 plays a role in the GH -- > IGF-I response to intense exercise
Rojas et al., Oncogene 2011 (Cell Transformation, Neoplastic...) : Moreover, we find that paracrine IL-6 stimulates the autocrine IL-6 loop and autocrine activation of insulin-like type I growth factor receptor ( IGF-IR ) to confer the tumorigenic property and also that activation of signal transducer and activator of transcription 3 ( STAT3 ) is critical in these processes ... Inhibition of STAT3 activation suppresses IL-6 induced upregulation of IGF-IR and its ligands, namely IGF-I and IGF-II
Jelinek et al., J Immunol 1997 (Multiple Myeloma) : The specificity of the IGF response was confirmed using an IGF-I receptor Ab, and additional studies demonstrated that IGF responsiveness did not result from induction of autocrine IL-6 expression
Franchimont et al., Endocrinology 1997 : We tested the effects of IL-6 and its soluble receptor (IL-6sR) on the expression of insulin-like growth factor (IGF)-I and IGF-II in cultured osteoblast enriched cells from fetal rat calvariae ( Ob cells )