◀ Back to AKT1

AKT1 — IL6

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: AKT1 → IL6 (increases, IL6 Activity) Podar et al., J Biol Chem 2004
  Evidence: We further demonstrate that these events are Src family tyrosine kinase-dependent and specifically identify the role of hematopoietic cell kinase (Hck) as a new Gab family adapter protein kinase. Conversely, inhibition of Src family tyrosine kinases by the pyrazolopyrimidine PP2, as in kinase-inactive Hck mutants, significantly reduces IL-6-triggered activation of extracellular signal-regulated kinase and AKT-1, leading to significant reduction of multiple myeloma cell proliferation and survival...

Text-mined interactions from Literome

Tu et al., Cancer Res 2000 (MAP Kinase Signaling System...) : In correlation with activation of PI 3-K, IGF-I also effectively activated the AKT kinase in 8226 and OCI-My5 cells, and IL-6 activated AKT in AF-10 and MH.60 cells ... However, although incapable of activating PI 3-K in 8226 and OCI-My5 cells, IL-6 successfully activated AKT in these MM lines, suggesting PI 3-K independent mechanisms of AKT activation
Kuo et al., Oncogene 2001 : Our previous works have demonstrated that both PI 3-K/Akt and STAT3 pathways were concomitantly activated and cooperatively mediated the anti-apoptotic effect of IL-6
Kunioku et al., Neurosci Lett 2001 : IL-6 stimulated phosphorylation of Akt, a downstream effector of PI3 kinase, and in the presence of LY294002, the phosphorylation of Akt was reduced to basal level
Hideshima et al., Oncogene 2001 (MAP Kinase Signaling System...) : IL-6 induces Akt/PKB phosphorylation in a time and dose dependent manner in MM.1S MM cells ... IL-6 induces Akt/PKB phosphorylation in a time and dose dependent manner in MM.1S MM cells ... Inhibition of Akt activation by the PI3-K inhibitor LY294002 partially blocked IL-6 triggered MEK/MAPK activation and proliferation in MM.1S cells, suggesting cross-talk between PI3-K and MEK signaling ... Finally, we show that IL-6 triggered PI3-K/Akt signaling in MM.1S cells inactivates forkhead transcriptional factor (FKHR), with related G1/S phase transition, whereas LY294002 blocks this signaling, resulting in upregulation of p27 ( KIP1 ) and G1 growth arrest
Mitsiades et al., Oncogene 2002 (Multiple Myeloma) : In contrast, IL-6 does not cause sustained NF-kappaB activation, induces less pronounced Akt activation and FKHRL-1 phosphorylation than IGF-1, and increases the expression of only survivin
Condorelli et al., Proc Natl Acad Sci U S A 2002 (Cardiomyopathy, Hypertrophic) : In fact, both IGF-1 and IL6-like cytokines induce hypertrophic and antiapoptotic signals in cardiomyocytes through PI3K dependent Akt activation
Pene et al., Oncogene 2002 (Multiple Myeloma) : IGF-1 but not IL-6 increased phosphorylation of Akt , FKHRL-1 and P70 ( S6K )
Shi et al., Mol Cancer Ther 2003 (Multiple Myeloma) : FTIs were also able to abrogate the IL-6 proliferative response of WT ras expressing MM cells, and this was associated with inhibition of IL-6 induced activation of ERK, AKT , and p70
Hsu et al., Oncogene 2004 (Multiple Myeloma) : Both DN constructs significantly prevented the IL-6 induced activation of AKT
Grzesiak et al., Int J Cancer 2005 (Adenocarcinoma...) : These results implicate GSK3 and PKB/Akt in the integrin mediated regulation of PTHrP, IL-6 and IL-8 in pancreatic cancer ... These results implicate GSK3 and PKB/Akt in the integrin mediated regulation of PTHrP, IL-6 and IL-8 in pancreatic cancer
Yasui et al., Cancer Res 2005 (Multiple Myeloma) : Finally, it down-regulates interleukin-6 induced phosphorylation of Akt , signal transducers and activators of transcription 3, and p42/44 mitogen activated protein kinase ; insulin-like growth factor-I triggered Akt phosphorylation ; and tumor necrosis factor alpha induced IkappaBalpha and nuclear factor-kappaB p65 phosphorylation
He et al., Mol Endocrinol 2006 (Insulin Resistance) : Interestingly, Akt phosphorylation was synergistically inhibited by IL-1alpha in the presence of IL-6
Jia et al., J Nutr 2006 : Inhibition of AKT suppressed both CREB/ATF1 phosphorylation and IL-6 transcription ... These data suggest that DHA consumption suppresses DON induced IL-6 transcription in macrophages in part by interfering with AKT dependent phosphorylation and subsequent binding of CREB/ATF1 to the IL-6 promoter
Wang et al., Biochem Biophys Res Commun 2006 (Insulin Resistance) : On the other hand, addition of TNF-alpha or IL-6 neutralizing antibodies to the supernatant of co-culture recovered both IRS-2 phosphorylation and Akt activation
Hanai et al., J Cell Biochem 2006 : In the present study, we investigated whether the phosphatidylinositol 3-kinase (PI3K)/Akt is involved in the PDGF-BB induced IL-6 synthesis in osteoblast-like MC3T3-E1 cells ... Taken together, these results strongly suggest that PI3K/Akt negatively regulates the PDGF-BB stimulated IL-6 synthesis in osteoblasts
Takai et al., Horm Metab Res 2006 : In the present study, we investigated whether phosphatidylinositol 3-kinase ( PI3-kinase ) /protein kinase B ( Akt ) is involved in TNF-alpha stimulated IL-6 synthesis in MC3T3-E1 cells ... Akt inhibitor, 1L-6-hydroxymethyl-CHIRO-inositol 2- ( R ) -2- O-methyl-3-O-octadecylcarbonate, significantly suppressed the TNF-alpha stimulated IL-6 synthesis, but the inhibitory effect was partial ... These results strongly suggest that PI3-kinase/Akt plays a role in the TNF-alpha stimulated IL-6 synthesis mainly independent of p44/p42 MAP kinase in osteoblasts
Choudhari et al., Mol Cancer Ther 2007 (Carcinoma, Hepatocellular...) : The interleukin 6-stimulated activation of STAT3 and Akt was inhibited not only by atiprimod but also by LY294002, a phosphoinositide-3-kinase-specific inhibitor, and by NS398, a cyclooxygenase-2-selective inhibitor
Xu et al., Rheumatology (Oxford) 2007 (Arthritis, Rheumatoid) : TNF-alpha induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha
Lee et al., American journal of physiology. Renal physiology 2007 : IL-6 also increased the phosphorylation of signal transducer and activator of transcription-3 ( STAT3 ), phosphoinositide-3 kinase (PI3K)/Akt , and mitogen activated protein kinases ( MAPKs ) in a time dependent manner
Tiberio et al., Hepatogastroenterology 2007 (Liver Cirrhosis) : In addition, we show that in cirrhosis the main molecular pathways downstream the receptors are intact and that IL-6 activates STAT3, AP-1 and NF-kappaB transcription factors, induces AKT and eNOS phosphorylation and increases hepato-cell proliferation and liver mass expansion in a dose dependent manner
Tang et al., J Immunol 2007 : Leptin induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt , NF-kappaB, and p300 pathway in microglia ... Leptin mediated IL-6 production was attenuated by OBRl receptor antisense oligonucleotide, PI3K inhibitor ( Ly294002 and wortmannin ), Akt inhibitor ( 1L-6-hydroxymethyl-chiro-inositol-2- ( ( R ) -2-O-methyl-3-O-octadecylcarbonate ) ), NF-kappaB inhibitor ( pyrrolidine dithiocarbamate ), IkappaB protease inhibitor ( L-1-tosylamido-2-phenylenylethyl chloromethyl ketone ), IkappaBalpha phosphorylation inhibitor ( Bay 117082 ), or NF-kappaB inhibitor peptide
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008 (Hyperglycemia) : Resveratrol inhibits high glucose induced PI3K/Akt/ERK dependent interleukin-17 expression in primary mouse cardiac fibroblasts
Suh et al., J Cell Physiol 2009 : In addition, IL-6 increased EGFR/src/FAK, PI3K/Akt phosphorylation and 2-DG uptake as well as GLUT-2 protein expression, which were blocked by AG 1478 ( EGF receptor inhibitor ), PP2 ( src family of tyrosine kinase inhibitor ), PI3K-specific siRNA, and a Akt inhibitor
Yuen et al., Diabetes 2009 : In contrast, IL-6 increased Akt phosphorylation ( Ser473 ) in hindlimb skeletal muscle and enhanced whole-body glucose disappearance and glucose uptake during the clamp
Xie et al., Clinical and vaccine immunology : CVI 2010 : IL-6 and TNF-alpha, but not IL-1beta, inhibited Akt phosphorylation within 15 min of insulin stimulation, but only IL-6 was inhibitory 30 min after stimulation
Hung et al., J Hypertens 2010 (Atherosclerosis) : In addition, IL-6 inhibited bradykinin stimulated Akt phosphorylation at Ser473 and Thr 308 without affecting the Akt protein expression
Nicoletti-Carvalho et al., J Endocrinol 2010 (Insulinoma...) : In the present study, we have demonstrated that PA selectively disrupts IL6 induced RAC-alpha serine/threonine-protein kinase ( AKT ) activation without interfering with signal transducer and activator of transcription 3 phosphorylation in RINm5F cells ... In this way, CHOP and ATF4 might mediate PA-induced TRIB3 expression and, by extension, the suppression of IL6 activation of pro-survival kinase AKT
Liu et al., Neurotox Res 2011 : IL-6 up-regulated the levels of phosphorylated STAT3 and Akt , and this was blocked by AG490 and LY294002, respectively ... These results suggest that IL-6 protects neurons against NMDA induced apoptosis, and that the IL-6 neuroprotection is jointly mediated by JAK-STAT3 and PI3K-Akt signaling pathways
Yasuda et al., J Pharmacol Sci 2011 : Pretreatment with anti-intercellular adhesion molecule-1 ( ICAM-1 ) antibody ( 20 µg/ml ) reversed the inhibitory effects of HA on LPS induced production of IL-6 and activation of Akt and NF-?B
Serrano-Marco et al., Diabetes 2011 : First, we observed that the PPAR-ß/-d agonist GW501516 prevented both IL-6 dependent reduction in insulin stimulated Akt phosphorylation and glucose uptake in adipocytes
März-Weiss et al., Cell Mol Neurobiol 2011 (Brain Injuries) : We found a rapid activation of Akt-kinase phosphorylation by PAP I with a peak at 15 min, whereas IL-6 induces Akt-phosphorylation lasting longer than 30 min. Phosphorylation of MAP-42/44 kinases is stimulated in a comparable fashion
Gu et al., Molecular cancer 2011 (Carcinoma, Hepatocellular...) : IL-17 induces AKT dependent IL-6/JAK2/STAT3 activation and tumor progression in hepatocellular carcinoma
Doroshow et al., Biochem Pharmacol 2012 : Exposure of HT-29 colon cancer cells, which express Nox1, to DPI and DTI confirmed their inhibitory effects on steady state ROS levels, and demonstrated decreased Stat, Erk1/2, and Akt signaling mediated by IL-4, IL-6 , IL-13, and IL-22, possibly due to a concomitant increase in tumor cell phosphatase activity
Wang et al., J Cell Biochem 2012 : We showed that IL-6 activated Akt and inhibited glycogen synthase kinase-3ß ( GSK-3ß ), highly associating with fascin-1 mRNA expression