Gene interactions and pathways from curated databases and text-mining

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CHUK — IL4

Text-mined interactions from Literome

Li et al., J Exp Med 1999 : Accordingly, IKKbeta-deficient cells are defective in activation of IKK and NF-kappaB in response to either tumor necrosis factor alpha or interleukin 1
Lgssiar et al., Experimental biology and medicine (Maywood, N.J.) 2004 (Diabetes Mellitus, Experimental) : Interleukin-11 prevented diabetes without affecting insulitis ; attenuated TNF-alpha and IFN-gamma response ; and stimulated IL-4 production and inhibited activation of IKK-alpha , NF-kappaB, and AP-1
Lamothe et al., J Biol Chem 2007 : Reconstituting TRAF6-deficent cells with various TRAF6 mutants, we clearly demonstrate the requirement for the TRAF6 RING domain and site-specific auto-ubiquitination of TRAF6 to activate IKK in response to interleukin-1
O'Connell et al., J Biol Chem 1998 : Recently, we have reported that the tumor necrosis factor and interleukin 1 signaling pathways activate two kinases, IKK1 and IKK2 ... Recently, we have reported that the tumor necrosis factor and interleukin 1 signaling pathways activate two kinases, IKK1 and IKK2