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EPO — IL3
Text-mined interactions from Literome
Logofetov et al., Arch Physiol Biochem 1998
(Anemia...) :
Short-term
effects of recombinant human
erythropoietin on serum levels of transforming growth factor beta-1, interleukin 1-alpha,
interleukin 3 , interferon gamma, and tumour necrosis factor alpha in patients with chronic renal failure on chronic haemodialysis were investigated
Kawasaki et al., Int J Hematol 2002
(Anemia, Diamond-Blackfan) :
We conclude that TPO enhances bone marrow erythropoiesis in patients with DBA in the
presence of
EPO and SCF and/or
IL-3
Miura et al., Mol Cell Biol 1991
:
In addition,
Epo uniquely
induced phosphorylation of a 72-kDa substrate while
IL-3 uniquely induced phosphorylation of a 140-kDa substrate
Fandrey et al., Ann N Y Acad Sci 1991
(Carcinoma, Hepatocellular...) :
A dose dependent decrease of up to 60 % in
Epo production was
induced by interleukin-1 beta,
interleukin-1 alpha, and tumor necrosis factor-alpha ( in that order of potency )
Ghinassi et al., Exp Hematol 2007
:
These results suggest that interleukin-3 and erythropoietin cooperate to establish the lineage-specific transcription factor milieu of erythroid cells
: interleukin-3 regulates mainly gene transcription and
erythropoietin consistently
increases mRNA and protein stability
Hattersley et al., Endocrinology 1991
(Bone Resorption) :
To analyze osteoclastic lineage, colonies were generated in semi-solid medium from mouse spleen cells in the
presence of
erythropoietin with either Wehi 3B-conditioned medium or
interleukin 3 (IL3)
Lifshitz et al., Haematologica 2010
:
The macrophages derived in-vitro from bone marrow cells expressed erythropoietin receptor transcripts, and in-vitro stimulation with
erythropoietin activated multiple signaling pathways, including signal transducer and activator of transcription ( STAT ) 1 and 5, mitogen activated protein kinase, phosphatidylinositol 3-kinase and nuclear factor kappa B. In-vitro erythropoietin treatment of these cells up-regulated their surface expression of CD11b, F4/80 and CD80, enhanced their phagocytic activity and nitric oxide secretion, and also
led to augmented
interleukin 12 secretion and decreased interleukin 10 secretion in response to lipopolysaccharide
de Wolf et al., Blood 1994
:
In contrast,
IL-3 in the
presence of
Epo did support CFU-Es, from CD34+/CD36- cells after 7 days in suspension culture
Muller et al., Exp Hematol 1993
(Polycythemia Vera) :
Recombinant human
mast cell growth factor supports erythroid colony formation in polycythemia vera in the
presence and absence of
erythropoietin and serum
Athanasiou et al., Oncogene 1996
:
A drug-selectable retrovirus expressing p135Gag-Myb-Ets induced an erythropoietin(Epo)-responsive phenotype in the cell lines FDC-P2, BaF3 and 32Dc123. Gag-Myb-Ets expression alone did not increase expression of GATA-1 or the
Epo receptor(EpoR) in the
presence of
IL3 , and infected cell lines express increased GATA-1 and EpoR only when IL3 was replaced by Epo in the culture media
Chin et al., Blood 1996
:
In the present study, we have shown that Epo or
IL-3 stimulation
induces binding of Stat5 to the tyrosine phosphorylated
Epo receptor (EpoR) or IL-3 receptor beta subunit ( betaIL3 ), respectively, in IL-3 dependent 32D cells expressing the EpoR