◀ Back to MAPK14
IL2RB — MAPK14
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IL12-mediated signaling events:
p38 alpha (MAPK14)
→
IL2/IL2R complex (IL2RA-IL2RB-IL2RG-IL2)
(modification, activates)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
p38 alpha (MAPK14)
→
IL2/IL2R complex (IL2RA-IL2RB-IL2RG-IL2)
(modification, activates)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1)
→
p38alpha-beta-active (MAPK14/MAPK11)
(modification, activates)
Hunt et al., J Biol Chem 1999, Crawley et al., J Biol Chem 1997
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1)
→
p38alpha-beta (MAPK14/MAPK11)
(modification, activates)
Hunt et al., J Biol Chem 1999, Crawley et al., J Biol Chem 1997
Evidence: mutant phenotype, other species
Text-mined interactions from Literome
Steinmetz et al., Endocrine 2001
:
These are the first studies to demonstrate the activation of Elk-1 by GHRH and the
activation of p38
MAPK and CHOP by GHRH, GHRH-RP, and
p75-92NH2
Williamson et al., J Biol Chem 2004
(Sarcoma, Ewing) :
These data demonstrate that sustained activation of p38 ( MAPK ) is essential for activation of the death cascade following exposure of Ewing 's sarcoma family of tumors cells to bFGF and provide evidence that activation of p38 (
MAPK )
results in an up-regulation of the death receptor
p75 ( NTR )
Morillo et al., Mol Cell Biol 2012
(Nerve Degeneration) :
We demonstrate that the activation of
p75 ( NTR ) by nerve growth factor (NGF)
induces nuclear p38 (
MAPK ) kinase activity, which leads to Thr phosphorylation and subsequent recruitment of E2F4 to the E2F-responsive cdc2 promoter