Gene interactions and pathways from curated databases and text-mining

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IL12A — IL2RA

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Bliss et al., J Immunol 1999 (Agranulocytosis...) : Production of IL-12 does not require TNFR p55 , and release of TNF-alpha occurs independently of IL-12
Nguyen et al., Eur J Immunol 2000 : Inhibition of IL-12 induced up-regulation of CD25 by a p38 mitogen activated protein ( MAP ) kinase inhibitor, SB203580, also ablates the synergism between IL-12 and Q126D
Valenzuela et al., J Immunol 2002 : In addition, high CD25 expression is substantially prolonged in the presence of IL-12
Sivori et al., Proc Natl Acad Sci U S A 2004 : In the presence of IL-12 , freshly isolated NK cells responded to double stranded RNA or unmethylated CpG DNA and expressed CD69 and CD25 activation markers
Tchórzewski et al., Med Sci Monit 2005 (Autoimmune Diseases...) : We analyzed reactive oxygen intermediate ( ROI ) production by peripheral blood granulocytes, the production of IL-2, IL-5, IL-10, IL-12 , and TNF-alpha cytokines by lymphocytes, and the activation of CD25 , CD26, CD69, CD71, and HLA DR antigen expression
King et al., J Immunol 2005 : Cutting edge : IL-12 induces CD4+CD25- T cell activation in the presence of T regulatory cells
Brahmachari et al., J Immunol 2009 : IL-12p40 ( 2 ) dose-dependently inhibited the expression of Foxp3 and CD25 , but not CD4
Ueta et al., Eur J Immunol 1996 : Recombinant human IL-12 stimulated gammadelta T cells, but not alphabeta T cells in peripheral blood mononuclear cells, to express CD25 on their surfaces, and to expand in number in vitro ... Anti-TNF-alpha monoclonal antibody inhibited IL-12 induced up-regulation of CD25 on gammadelta T cells, suggesting that endogenous TNF-alpha may play a role in IL-12 induced activation of gammadelta T cells ... Furthermore, IL-12 up-regulated TNF receptors on gammadelta T cells in vitro : TNF-alpha binding to its receptor induced CD25 expression on the gammadelta T cells in an autocrine or paracrine fashion, or perhaps both