UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to IL22

IL22 — IL22RA1

Pathways - manually collected, often from reviews:

BioCarta il22 soluble receptor signaling pathway: IL-22/IL-22/IL-22R1/JAK1 complex (IL22-IL22RA1-JAK1) → IL-22/IL-22/IL-10R2C/TYK2 complex (IL22-IL10RA-TYK2) (modification, collaborate)
BioCarta il22 soluble receptor signaling pathway: IL-22/IL-22/IL-22R1/JAK1 complex (IL22-IL22RA1-JAK1) → IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/JAK1/JAK1/IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/IL-22/IL-22 complex (IL22-IL22RA1-IL10RA-TYK2-JAK1) (modification, collaborate)
BioCarta il22 soluble receptor signaling pathway: IL-22/IL-22/IL-10R2C/TYK2 complex (IL22-IL10RA-TYK2) → IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/JAK1/JAK1/IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/IL-22/IL-22 complex (IL22-IL22RA1-IL10RA-TYK2-JAK1) (modification, collaborate)
BioCarta il22 soluble receptor signaling pathway: STATs (STAT3/STAT5A/STAT1/STAT5A/STAT5B/STAT5B) → IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/JAK1/JAK1/IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/IL-22/IL-22 complex (IL22-IL22RA1-IL10RA-TYK2-JAK1) (modification, collaborate)
BioCarta il22 soluble receptor signaling pathway: IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/JAK1/JAK1/IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/IL-22/IL-22 complex (IL22-IL22RA1-IL10RA-TYK2-JAK1) → STATS/STATS complex (STAT3_STAT5A_STAT1_STAT5A_STAT5B_STAT5B) (modification, activates)
BioCarta il22 soluble receptor signaling pathway: IL-22/IL-22/IL-22R1/JAK1 complex (IL22-IL22RA1-JAK1) → IL-22R1/JAK1 complex (IL22RA1-JAK1) (modification, collaborate)
BioCarta il22 soluble receptor signaling pathway: IL-22/IL-22/IL-22R1/JAK1 complex (IL22-IL22RA1-JAK1) → IL-22 (IL22) (modification, collaborate)
BioCarta il22 soluble receptor signaling pathway: IL-22R1/JAK1 complex (IL22RA1-JAK1) → IL-22 (IL22) (modification, collaborate)
KEGG Cytokine-cytokine receptor interaction: IL22 → Complex of IL10RB-IL22RA1 (protein-protein, activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Biogrid Interaction: IL22RA1 — IL22 (physical association, affinity chromatography technology) Xie et al., J Biol Chem 2000 *
IRef Biogrid Interaction: IL22RA1 — IL22 (direct interaction, pull down) Kotenko et al., J Biol Chem 2001 *
IRef Dip Interaction: IL22RA1 — IL22 (direct interaction, surface plasmon resonance) Jones et al., Structure 2008 *
IRef Dip Interaction: IL22RA1 — IL22 (direct interaction, x-ray crystallography) Jones et al., Structure 2008 *
IRef Dip Interaction: IL22RA1 — IL22 (direct interaction, surface plasmon resonance) Yoon et al., Structure 2010 *
IRef Hprd Interaction: IL22RA1 — IL22 (in vivo) Kotenko et al., J Biol Chem 2001 *
IRef Innatedb Interaction: IL22RA1 — IL22 (unknown, -) Jones et al., Structure 2008 *
IRef Intact Interaction: IL22RA1 — IL22 (direct interaction, x-ray crystallography) Bleicher et al., FEBS Lett 2008 *