Gene interactions and pathways from curated databases and text-mining

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IL2 — PRKAR2A

Text-mined interactions from Literome

Poluektova et al., Immunopharmacology 1999 : In this report we explore the role of PKA in histamine mediated effects on IL-2 mRNA expression and IL-2 protein secretion
Bryce et al., Immunopharmacology 1999 : It has been demonstrated that the inhibitory effects of pharmacological elevations in cAMP on human T cell proliferation and IL-2 production do not require PKA activity
Herring et al., Cell Signal 2001 (MAP Kinase Signaling System) : Therefore, the objective of the present studies was to determine the role of cAMP and protein kinase A (PKA) in the CBN mediated inhibition of IL-2 , CREB, and NF-kappaB in PMA/Io activated thymocytes
Williams et al., J Immunol 2002 : Disruption of the AKAP-PKA interaction caused high levels of IL-2 , IL-4, IL-5, and IFN-gamma production in the absence of stimulation via CD3epsilon and CD28 molecules
Hughes-Fulford et al., Cell Signal 2005 : Gene expression of IL-2R ( alpha ) and IFN(gamma) was dependent on PKA in S49 wt cells but not in kin- mutants ... Taken together, these results suggest that the PKA in addition to PKC and MAPK pathways plays a role in early T-cell activation and induction of IL-2, IL-2R ( alpha ) and IFN(gamma) gene expression
Rodriguez et al., J Biol Chem 2013 : Taken together, these findings suggest that Fsk activation of adenylate cyclase and PKA can negatively regulate IL-2 signaling at multiple levels that include IL-2R complex formation and Jak3/Stat5 activation
Neumann et al., EMBO J 1995 : In CD4+ T helper cells, stimulation of PKA leads to suppression of interleukin 2 (IL-2) induction, while induction of the genes coding for the lymphokines IL-4 and IL-5 is enhanced ... We show that the differential effect of PKA activity on induction of the IL-2 and IL-4 genes is mediated through their promoters ... Mutations preventing factor binding to the IL-2 kappa B site result in a loss of PKA mediated suppression of IL-2 promoter activity
Sugiyama et al., J Immunol 1997 : The role of cAMP dependent protein kinase (PKA) in the regulation of TCR triggered IL-2 secretion was studied by transfecting T hybridoma cells with cDNA encoding the inhibitory regulatory subunit ( RI alpha ) of PKA with mutations in cAMP binding sites ( RI alpha ( m ) ) or by pretreating T cells with catalytic subunit-alpha ( C alpha ) antisense mRNA oligonucleotides