Gene interactions and pathways from curated databases and text-mining

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CREB1 — IL2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Herring et al., Cell Signal 2001 (MAP Kinase Signaling System) : One of these compounds, cannabinol ( CBN ) has been shown to inhibit interleukin-2 (IL-2) expression and the activation of cAMP response element binding protein ( CREB ) and nuclear factor for immunoglobulin kappa chain in B cells ( NF-kappaB ) following phorbol-12-myristate-13 acetate ( PMA ) plus ionomycin ( Io ) treatment of thymocytes
Solomou et al., J Immunol 2001 : These findings show that CREB plays a major role in the transcriptional regulation of IL-2 and that a major pathway for the activation of CREB and its subsequent binding to the IL-2 promoter/enhancer in normal T cells is mediated by PKC-theta
Thomas et al., Arch Toxicol 2005 : In this study we address the effects of IL-2 and IL-12 on the TBT induced decreases in NK-cell levels of the cytotoxic proteins, their mRNAs, and CREB phosphorylation
Bostik et al., J Immunol 2007 (Disease Susceptibility...) : CD4+ T cells from simian immunodeficiency virus disease-resistant sooty mangabeys produce more IL-2 than cells from disease-susceptible species : involvement of p300 and CREB at the proximal IL-2 promoter in IL-2 up-regulation
Kaiser et al., Eur J Immunol 2007 : This correlated to a reduction in the TCR induced up-regulation of the IL-2 receptor CD25 and a requirement for MSK in IL-2 induced CREB phosphorylation
Feuerstein et al., J Immunol 1995 : By using specific Abs in a gel mobility shift assay, we identified two known CREB/ATF transcription factors in the IL-2 induced CRE complexes : the CRE binding factor ( CREB ) , and ATF1 ... The induction of CREB binding by IL-2 was not associated with an increase in its abundance but was associated with a major increase in CREB phosphorylation that was particularly prominent at late G1/S
Good et al., EMBO J 1996 : In the present study, we demonstrate that neither NF-kappa B/Rel nor CREB/ATF is sufficient for Tax mediated activation of the IL-2 promoter
Guyot et al., Immunol Lett 1998 : However, while neither IL-2 nor CD3 cross linking alone induced P-CREB , a 4.5-fold increase in phosphorylation of CREB within 1 h of IL-2/CD3 co-stimulation was observed
Belkowski et al., J Immunol 1998 : These results indicate that IL-2 induces a rapamycin-sensitive, cAMP independent CREB kinase activity in L2 cells