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AKT1 — IL2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Kitaura et al., J Exp Med 2000
:
Akt in turn can
regulate positively the transcriptional activity of
interleukin (IL)-2 and tumor necrosis factor (TNF)-alpha promoters ... Importantly,
Akt regulates the production and secretion of
IL-2 and TNF-alpha in FcepsilonRI stimulated mast cells
Ciprés et al., FEBS Lett 2001
:
Deletion of the acidic-rich domain of the IL-2 receptor beta chain (IL-2Rbeta) prevents association of Src tyrosine kinases to the receptor, as well as
IL-2 induced
Akt activation
Mazzoni et al., J Immunol 2002
:
Inhibition of mitogenic and peptide-specific responses is not associated with a loss in IL-2 production or inability to up-modulate the early activation markers, CD69 and CD25, but results in direct impairment of the three IL-2R signaling pathways, as demonstrated by the lack of Janus kinase 3, STAT5, extracellular signal regulated kinase, and
Akt phosphorylation in
response to
IL-2
Kreisel et al., Am J Transplant 2002
:
Surprisingly, while
IL-2 also
induces phosphorylation of
Akt , it does not initiate cell cycle progression in this population of primary undivided cells
Kawauchi et al., J Immunol 2005
(Leukemia, Lymphocytic, Chronic, B-Cell...) :
IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol
3'-kinase/Akt , heat shock protein 90, and mammalian target of rapamycin in transformed NK cells ... ERK1/2 and
Akt kinase ( Akt ) were
activated by
IL-2 stimulation
Gorjão et al., J Lipid Res 2007
:
PA, SA, DHA, and EPA decreased JAK1, JAK3, STAT5, and
Akt phosphorylation
induced by
IL-2 , but OA and LA did not cause any effect
Marzec et al., Blood 2008
(Lymphoma, T-Cell, Cutaneous) :
The mTORC1,
PI3K/Akt , and MEK/ERK pathways could also be
activated by
IL-2 in the primary leukemic, mitogen preactivated CTCL cells
Bae et al., J Microbiol Biotechnol 2008
:
IL-2 increased the ROS level and phosphorylation of
Akt in human umbilical vein endothelial cells ( HUVECs ) ... The effect of
IL-2 on angiogenesis and tube formation was
mediated by ROS and
Akt
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008
(Hyperglycemia) :
Resveratrol inhibits high glucose induced
PI3K/Akt/ERK dependent
interleukin-17 expression in primary mouse cardiac fibroblasts
Chan et al., J Pathol 2010
(Lymphoma, Extranodal NK-T-Cell) :
Similar to BCL10, the expression and nuclear translocation of BCL3 were induced by
IL2 in an
Akt dependent manner
Macintyre et al., Immunity 2011
:
In cytotoxic T cells ( CTL ),
Akt , also known as protein kinase B, is
activated by the T cell antigen receptor ( TCR ) and the cytokine
interleukin 2 (IL-2) ... Here we have shown that
Akt does not
mediate IL-2- or TCR induced cell metabolic responses ; rather, this role is assumed by other Akt related kinases
Ahmed et al., Proc Natl Acad Sci U S A 1997
:
Akt activation by
IL-2 depends on PI3-kinase signals transduced via the S region of the IL-2R beta and is linked to the translocation of Akt to the cell membrane ... The
activation of
Akt by
IL-2 via the PI3-kinase and the rescue of the PI3-kinase mediated antiapoptotic and proliferative IL-2 signals by catalytically active Akt indicate that these signals are transduced by Akt
Reif et al., J Biol Chem 1997
:
Herein, we demonstrate that
PKB is
activated by
IL-2 in a PI 3-kinase dependent fashion
Brennan et al., Immunity 1997
:
Protein kinase B (PKB) is
activated by
IL-2 via PI3K