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IGF1 — IL1B

Text-mined interactions from Literome

Spies et al., Gene Ther 2001 (Burns) : Local IGF-1 gene transfer attenuates the mRNA expression of the inflammatory cytokines IL-1beta and TNF-alpha in the burn wound
Anwar et al., Circulation 2002 (Arteriosclerosis) : IL-1beta , IL-6, and IFN-gamma did not regulate IGF-1, IGF-1 receptor (R), or IGF binding proteins ( IGFBPs )
Wang et al., Arthritis Rheum 2003 : The effects of IGF-1 on the expression of IGF-1, IL-1alpha, and IL-1beta and their respective receptor systems, the aggrecan core protein, and CII were determined by flow cytometry
Linkhart et al., Endocrinology 1992 (Bone Resorption) : To determine whether increased or decreased IGF-I production in bone might mediate some of the effects of IL-1 on bone turnover, the effects of IL-1 alpha and IL-1 beta on IGF-I release from neonatal mouse calvaria in organ culture were examined ... IL-1 alpha and IL-1 beta stimulated resorption and increased the release of IGF-I into the medium during 6 days of culture
Broussard et al., J Immunol 2004 : In the absence of exogenous IGF-I , IL-1beta ( 1 ng/ml ) did not impair muscle cell development
Lin et al., Endocrinology 1992 : IL-1 beta also suppressed IGF-I mRNA expression in Leydig cells in vitro in a time- and dose dependent fashion ... IL-1 beta ( 100 ng/ml ) inhibited IGF-I mRNA expression to about 10 % of the controls ( P less than 0.01 )
Porter et al., J Cell Physiol 2006 : Northern blot analysis suggested IL-1beta regulation of IGF-I and, to some extent, IGF-IR was mediated by transcription ; however, the cytokine did not affect IGFBP-2 expression
Porter et al., Tissue Eng 2007 : Alginate encapsulation impacts the insulin-like growth factor-I system of monolayer expanded equine articular chondrocytes and cell response to interleukin-1beta
Miller et al., Journal of inflammation (London, England) 2007 : Progrado prevented IL-1beta induced suppression of IGF-1 production from human cartilage explants as well as stimulating basal IGF-1 production ( P < 0.05 )
Hijikawa et al., Shock 2008 (Liver Failure) : Insulin-like growth factor 1 inhibited increases in TNF-alpha, IL-1 beta , and cytokine induced neutrophil chemoattractant 1 caused by GalN/LPS in serum and liver and enhanced serum IL-10
Honsho et al., Circ Res 2009 (Endomyocardial Fibrosis...) : Stretch of CFs, rather than CMs, abundantly induced the generation of IL-1beta and IGF-1, whereas such IGF-1 induction was markedly decreased in IL-1beta-deficient CFs. IL-1beta released by stretch is at a low level unable to induce IL-6 but sufficient to stimulate IGF-1 production
Ueland et al., J Clin Endocrinol Metab 2010 (Acromegaly...) : In vitro effects of GH/IGF-I on IL-1beta/IL-1Ra in THP-1 macrophages and human white adipocytes as well as effects of GH/IGF-I in combination with carboxylated and undercarboxylated OCN on glucose stimulated insulin release in human pancreatic islets were also investigated ... In macrophages, IGF-I/GH significantly decreased the release of IL-1Ra and increased IL-1beta , suggesting that the decreased circulating IL-1Ra levels in acromegaly could reflect both direct and indirect mechanisms
Matsumoto et al., Ann Rheum Dis 1994 : Effects of interleukin-1 beta on insulin-like growth factor-I autocrine/paracrine axis in cultured rat articular chondrocytes ... To clarify the interaction of tissue destruction and repair of articular cartilage during inflammation, the effects of interleukin-1 beta (IL-1 beta) on the expression of insulin-like growth factor I (IGF-I) , its receptor, and its binding proteins were examined ... IL-1 beta induced the secretion of IGF-I and IGF binding protein in chondrocytes ; this was not inhibited by indomethacin ( 5 micrograms/ml ) ... IL-1 beta also increased the number of IGF-I receptors but had no effect on receptor affinity
Wang et al., Endocrinology 1995 : In conclusion, IL-1 beta inhibits IGF-I but increases IGFBP-3 expression in Leydig cells, and this may contribute to the inhibitory effects of IL-1 beta on Leydig cell steroidogenesis
Costantino et al., Endocrinology 1996 (Breast Neoplasms) : We examined the effects of IL-1 alpha and IL-1 beta on insulin and insulin-like growth factor I (IGF-I) stimulation of cell growth and found that both IL-1s inhibited anchorage dependent and independent growth of MCF-7 breast cancer cells
Wolf et al., Eur J Endocrinol 1996 : In cells not stimulated with GH, modest inhibitory effects of IL-1 beta on GH receptor mRNA, IGF-I mRNA and IGF-I protein levels were seen ... In conclusion, we demonstrated that in rat hepatocytes in primary culture IL-1 beta and TNF-alpha inhibited GH-stimulated IGF-I synthesis
Thissen et al., Endocrinology 1997 : To determine whether cytokines can directly inhibit the production of IGF-I by the liver, we investigated the regulation of IGF-I gene expression by interleukin (IL)-1 beta , IL-6, and tumor necrosis factor (TNF)-alpha ( 10 ng/ml ) in a model of rat primary cultured hepatocytes