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HIF1A — IL1B
Text-mined interactions from Literome
Hellwig-Bürgel et al., Blood 1999
(Anoxia...) :
Only
IL-1beta increased
HIF-1alpha protein levels
Haddad et al., Eur Cytokine Netw 2002
:
Furthermore, evidence that reactive oxygen species ( ROS ) signaling mediates interleukin
(IL)-1 beta dependent regulation of
HIF-1 alpha has yet to be ascertained in alveolar epithelial cells ... Recombinant human
IL-1 beta induced , in a time dependent manner, the nuclear translocation of
HIF-1 alpha , an effect associated with up-regulating the activity of this transcription factor under normoxic conditions ... The antioxidants, dimethyl sulfoxide ( DMSO ) and 1,3-dimethyl-2-thiourea ( DMTU ), purported to be prototypical scavengers of H2O2 and *OH, attenuated, in a dose dependent manner,
IL-1 beta induced
HIF-1 alpha nuclear translocation and activation ... Inhibition of the mitochondrion complex I nicotinamide adenine dinucleotide phosphate dependent oxidase by diphenylene iodonium ( DPI ), which blocks the conversion of ubiquinone -- > ubiquinol, abrogated
IL-1 beta dependent nuclear translocation and activation of
HIF-1 alpha ... Similarly, interrupting the respiratory chain with potassium cyanide reversed the excitatory
effect of
IL-1 beta on
HIF-1 alpha nuclear translocation and activation
Jung et al., FASEB J 2003
(Inflammation...) :
IL-1beta mediated up-regulation of
HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis
Hellwig-Bürgel et al., Cell Physiol Biochem 2005
:
The study shows that PI3K but not MAPKK-1 inhibition resulted in the loss of hypoxic and
IL-1beta induced
HIF-1alpha accumulation, whereas VEGF synthesis was reduced by either intervention
Zhang et al., J Neuroimmunol 2006
:
Inhibition of
HIF-1alpha degradation by proteasome inhibitor, MG-132,
potentiated hypoxia induced
IL-1beta release from human astrocytes, and this response was blocked in the presence of CdCl2. Mouse astrocytes with Hif1alpha+/- genotype demonstrated attenuated up-regulation of both HIF-1alpha and IL-1beta by hypoxia and CoCl2
Kimura et al., Br J Pharmacol 2006
(Burns) :
3. In human keratinocyte cultures ( HaCaT cells ), ginsenoside Rb1 ( 100 fg ml(-1) to 1 ng ml(-1) ) enhanced VEGF production
induced by
IL-1beta and expression of hypoxia-inducible factor
(HIF)-1alpha
Argaw et al., J Immunol 2006
(Anoxia...) :
Suggesting functional significance, we found that expression of
IL-1beta in the brain
induced astrocytic expression of
HIF-1alpha , VEGF-A, and BBB permeability ... In addition, we confirmed VEGF-A to be a potent inducer of BBB permeability and angiogenesis, and demonstrated the importance of
IL-1beta induced
HIF-1alpha in its regulation
Mojsilovic-Petrovic et al., Journal of neuroinflammation 2007
:
We have recently shown that hypoxia induced expression of
IL-1beta in astrocytes is
mediated by
HIF-1alpha
Stasinopoulos et al., Cancer Biol Ther 2009
(Anoxia...) :
These data suggest that the profound effects of COX-2 silencing on inhibiting invasion, tumor growth and metastasis from MDA-MB-231 cells are dependent on the induction of
IL-1beta dependent COX-2 and
HIF-1alpha but are independent of hypoxia
Zhu et al., Osteoarthritis Cartilage 2009
:
Additionally, IL-1beta stimulated both
HIF-1alpha and PAI-1 in articular chondrocytes, and the
IL-1beta mediated induction of PAI-1 was
inhibited partly by HIF-1alpha silencing