Gene interactions and pathways from curated databases and text-mining

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IL1A — STAT3

Text-mined interactions from Literome

Cisowski et al., Folia Histochem Cytobiol 2002 : IL-1 mediated inhibition of IL-6 induced STAT3 activation is modulated by IL-4, MAP kinase inhibitors and redox state of HepG2 cells
Uno et al., Horm Metab Res 2008 : Addition of anti-IL-6 neutralizing antibody to the medium or overexpression of dominant negative STAT3 decreased the IL-1alpha stimulated STAT3 activation and SOCS3 induction, and ameliorated insulin signaling
Tanabe et al., Journal of neuroinflammation 2011 : Midazolam markedly suppressed IL-1ß stimulated STAT3 phosphorylation without affecting the phosphorylation of p38 MAP kinase, SAPK/JNK or I?B
Mori et al., Int Immunol 2011 (Arthritis, Experimental...) : Leukemia inhibitory factor expression and STAT3 activation by IL-1ß were mainly promoted by IL-6 but still induced in IL-6-deficient cells
Kondo et al., Arch Biochem Biophys 2013 : SP600125 remarkably suppressed the IL-1 induced phosphorylation of both I?B and NF-?B, whereas SP600125 failed to affect the IL-1 induced phosphorylation of AMPK, STAT3 or Src
Reddy et al., Proc Soc Exp Biol Med 1998 : These data reveal that collagenase gene expression can be regulated by the impairment of IL-1 stimulated NF-kappaB, STAT3 , and AP-1 activities, and can highlight a possible molecular mechanism for the anti-inflammatory effects of glucocorticoids