Gene interactions and pathways from curated databases and text-mining

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AKT1 — IL1A

Text-mined interactions from Literome

Madge et al., J Biol Chem 2000 : Here we report that both TNF and IL-1 activate the anti-apoptotic protein kinase Akt in growth factor and serum deprived EC, assessed by Western blotting for phospho-Akt
Chen et al., J Biol Chem 2002 : In human embryonic kidney 293 cells, IL-1beta induces IkappaB kinase beta (IKKbeta) activation, IkappaBalpha degradation, NF-kappaB transactivation, and weak Akt activation
Rölz et al., Br J Pharmacol 2003 : 4 In addition, IL-1beta also triggers a short-term and transient inhibitory effect on ATP induced PKB activation which is maximal after 2-5 min of pre-incubation with IL-1beta
Diem et al., Mol Cell Neurosci 2003 (Nerve Degeneration) : Western blot analysis revealed an IL-1 beta induced IL-1RI dependent upregulation of phospho-Akt
Cenni et al., Biochem J 2003 : Interestingly, the association of Akt with recombinant IRAK2 is decreased by stimulation with IL-1 , and is favoured by pre-treatment with phosphatase
Choi et al., FEBS Lett 2004 : Complete inhibition of interleukin (IL)-1beta induced Akt phosphorylation occurred at 50 microM LY29 or 100 nM WM
He et al., Mol Endocrinol 2006 (Insulin Resistance) : Insulin stimulated Akt phosphorylation and 2-deoxyglucose uptake were not inhibited only by IL-1alpha ... Interestingly, Akt phosphorylation was synergistically inhibited by IL-1alpha in the presence of IL-6
Tong et al., Neurobiol Aging 2008 : In trophic support deprived neurons, IL-1 beta compromised the PI3-K/Akt pathway mediated protection by BDNF and suppressed Akt activation
Grzelkowska-Kowalczyk et al., Cell Mol Biol Lett 2010 : The aim of this study was to compare the effects of TNF-alpha, IL-1beta and IFN-gamma on the activation of protein kinase B (PKB) , p70 ( S6k ), mitogen activated protein kinase ( MAPK ) and p90 ( rsk ), and on IGF-I stimulated glucose uptake and protein synthesis in mouse C2C12 myotubes
Zhang et al., J Pathol 2010 (Colitis...) : Our results showed that GDNF resulted in a significant reduction in enhanced permeability, inhibited MPO activity, IL-1beta and TNF-alpha expression, and increased ZO-1 and Akt expression
Llacuna et al., Hepatology 2010 (Liver Diseases...) : I/R induced early hepatic protein kinase B ( AKT ) phosphorylation in WT mice but not in Gas6 ( -/- ) mice without significant changes in c-Jun N-terminal kinase phosphorylation or nuclear factor kappa B translocation, whereas hepatic interleukin-1ß (IL-1ß) and tumor necrosis factor (TNF) messenger RNA levels were higher in Gas6 ( -/- ) mice versus WT mice
Buhrmann et al., J Biol Chem 2011 (Inflammation) : Curcumin suppressed IL-1ß induced PI-3K p85/Akt activation and its association with IKK
Chi et al., Arthritis Rheum 2011 (Arthritis, Rheumatoid) : IL-1ß also stimulated Akt phosphorylation and nuclear translocation
Bhawal et al., J Cell Biochem 2012 (Bacteroidaceae Infections...) : This is supported by the following data : ( 1 ) IL-1ß induces 473 serine phosphorylation of Akt; (2) IL-1ß mediated Akt activation occurs in a PI-3K dependent manner, and specific inhibition of PI-3K prevents Akt phosphorylation ; and ( 3 ) inhibition of Akt prevents IL-1ß mediated DEC1 and HIF-1a induction
Busch et al., J Biol Chem 2012 : Inhibition of PI3K by wortmannin attenuated IL-1ß induced Akt and p65 acetylation, suggesting that p65 is a downstream component of PI3K/Akt in these responses
Gulen et al., Immunity 2012 : Via biochemical and genetic approaches, the kinases IKKi and GSK3a were identified as the critical intermediate signaling components for IL-1 induced AKT activation, which in turn activated mTOR ... Upon IL-1 stimulation, IKKi was activated to mediate GSK3a phosphorylation at S21, thereby inactivating GSK3a to promote IL-1 induced AKT-mTOR activation
Ko et al., PloS one 2013 (Carcinoma, Squamous Cell) : The involvement of Akt and NF-?B signaling pathways in the EGF induced IL-1ß gene expression was confirmed by knockdown of RelA and Akt in cells or treating cells with Akt and NF-?B inhibitors, LY294002 and parthenolide, respectively