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AKT1 — IL1A
Text-mined interactions from Literome
Madge et al., J Biol Chem 2000
:
Here we report that both TNF and
IL-1 activate the anti-apoptotic protein kinase
Akt in growth factor and serum deprived EC, assessed by Western blotting for phospho-Akt
Chen et al., J Biol Chem 2002
:
In human embryonic kidney 293 cells,
IL-1beta induces IkappaB kinase beta (IKKbeta) activation, IkappaBalpha degradation, NF-kappaB transactivation, and weak
Akt activation
Rölz et al., Br J Pharmacol 2003
:
4 In addition,
IL-1beta also
triggers a short-term and transient inhibitory effect on ATP induced
PKB activation which is maximal after 2-5 min of pre-incubation with IL-1beta
Diem et al., Mol Cell Neurosci 2003
(Nerve Degeneration) :
Western blot analysis revealed an IL-1 beta induced
IL-1RI dependent upregulation of
phospho-Akt
Cenni et al., Biochem J 2003
:
Interestingly, the association of
Akt with recombinant IRAK2 is decreased by
stimulation with
IL-1 , and is favoured by pre-treatment with phosphatase
Choi et al., FEBS Lett 2004
:
Complete inhibition of
interleukin (IL)-1beta induced
Akt phosphorylation occurred at 50 microM LY29 or 100 nM WM
He et al., Mol Endocrinol 2006
(Insulin Resistance) :
Insulin stimulated
Akt phosphorylation and 2-deoxyglucose uptake were not
inhibited only by
IL-1alpha ... Interestingly,
Akt phosphorylation was synergistically
inhibited by
IL-1alpha in the presence of IL-6
Tong et al., Neurobiol Aging 2008
:
In trophic support deprived neurons,
IL-1 beta compromised the PI3-K/Akt pathway mediated protection by BDNF and
suppressed Akt activation
Grzelkowska-Kowalczyk et al., Cell Mol Biol Lett 2010
:
The aim of this study was to compare the
effects of TNF-alpha,
IL-1beta and IFN-gamma on the activation of
protein kinase B (PKB) , p70 ( S6k ), mitogen activated protein kinase ( MAPK ) and p90 ( rsk ), and on IGF-I stimulated glucose uptake and protein synthesis in mouse C2C12 myotubes
Zhang et al., J Pathol 2010
(Colitis...) :
Our results showed that GDNF resulted in a significant reduction in enhanced permeability,
inhibited MPO activity,
IL-1beta and TNF-alpha expression, and increased ZO-1 and
Akt expression
Llacuna et al., Hepatology 2010
(Liver Diseases...) :
I/R
induced early hepatic protein kinase B (
AKT ) phosphorylation in WT mice but not in Gas6 ( -/- ) mice without significant changes in c-Jun N-terminal kinase phosphorylation or nuclear factor kappa B translocation, whereas hepatic
interleukin-1ß (IL-1ß) and tumor necrosis factor (TNF) messenger RNA levels were higher in Gas6 ( -/- ) mice versus WT mice
Buhrmann et al., J Biol Chem 2011
(Inflammation) :
Curcumin suppressed
IL-1ß induced PI-3K
p85/Akt activation and its association with IKK
Chi et al., Arthritis Rheum 2011
(Arthritis, Rheumatoid) :
IL-1ß also
stimulated Akt phosphorylation and nuclear translocation
Bhawal et al., J Cell Biochem 2012
(Bacteroidaceae Infections...) :
This is supported by the following data : ( 1 )
IL-1ß induces 473 serine phosphorylation of Akt; (2) IL-1ß mediated Akt activation occurs in a PI-3K dependent manner, and specific inhibition of PI-3K prevents Akt phosphorylation ; and ( 3 ) inhibition of
Akt prevents IL-1ß mediated DEC1 and HIF-1a induction
Busch et al., J Biol Chem 2012
:
Inhibition of PI3K by wortmannin attenuated
IL-1ß induced
Akt and p65 acetylation, suggesting that p65 is a downstream component of PI3K/Akt in these responses
Gulen et al., Immunity 2012
:
Via biochemical and genetic approaches, the kinases IKKi and GSK3a were identified as the critical intermediate signaling components for
IL-1 induced
AKT activation, which in turn activated mTOR ... Upon IL-1 stimulation, IKKi was activated to mediate GSK3a phosphorylation at S21, thereby inactivating GSK3a to promote
IL-1 induced
AKT-mTOR activation
Ko et al., PloS one 2013
(Carcinoma, Squamous Cell) :
The
involvement of
Akt and NF-?B signaling pathways in the EGF induced
IL-1ß gene expression was confirmed by knockdown of RelA and Akt in cells or treating cells with Akt and NF-?B inhibitors, LY294002 and parthenolide, respectively