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IL18 — STAT3

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL27-mediated signaling events: STAT1-3 (dimer) (STAT1/STAT3) → IL18 (IL18) (transcription, activates) Pflanz et al., J Immunol 2004

Text-mined interactions from Literome

O'Brien et al., J Biol Chem 1999 : STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130 utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid hormone
Kalina et al., J Immunol 2000 (MAP Kinase Signaling System) : IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21
Sahar et al., Circ Res 2005 (Arteriosclerosis...) : Finally, dominant negative STAT-3 mutant blocked Ang II-induced IL-18Ralpha promoter activation in CHO cells overexpressing AT1a receptor and IL-18Ralpha mRNA expression in HVSMC
Ozawa et al., Journal of ophthalmology 2011 : In innate chorioretinal inflammation, interleukin-6 family ligands induce STAT3 activation in photoreceptors, which causes UPS mediated excessive degradation of the visual substance, rhodopsin