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IL18 — MAPK14

Pathways - manually collected, often from reviews:

• KEGG Tuberculosis: MAPK11/MAPK12/MAPK13/MAPK14 → IL18 (gene expression, expression)

Text-mined interactions from Literome

McDermott et al., J Biol Chem 2002 : Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1
Yan et al., J Biol Chem 2002 : This model probiotic also inhibits activation of the pro-apoptotic p38/mitogen activated protein kinase by tumor necrosis factor, interleukin-1alpha , or gamma-interferon
Jee et al., J Invest Dermatol 2002 (Carcinoma, Basal Cell...) : Next, interleukin-6 stimulation elicited extracellular signal regulated kinase activation in basal cell carcinoma cells, and the mitogen activated protein kinase inhibitor, PD98059, could affect this response without affecting the interleukin-6-medi ated Mcl-1 upregulation
Lee et al., Proc Natl Acad Sci U S A 2004 (Fever...) : Five minutes after exposure to either cytokine, phosphorylation of mitogen activated protein kinase ( MAPK ) p38 was present ; specific inhibition of p38 MAPK reduced IL-18 activity to background levels
Mason et al., Infect Immun 2004 : TRAF6 dependent mitogen activated protein kinase activation differentially regulates the production of interleukin-12 by macrophages in response to Toxoplasma gondii
Elbim et al., Clin Diagn Lab Immunol 2005 : Flow cytometric analysis of intact PMNs in whole blood showed that IL-18 increased p38MAPK phosphorylation and tyrosine phosphorylation
Park et al., J Invest Dermatol 2005 (MAP Kinase Signaling System) : In order to investigate whether the mitogen activated protein kinase ( MAPK ) signaling pathway is involved in the downregulation of IL-18 production, cells were pre treated with SB203580, an inhibitor of p38 MAPK, prior to the addition of CRH
Niyonsaba et al., J Immunol 2005 (MAP Kinase Signaling System) : The human beta-defensins ( -1, -2, -3, -4 ) and cathelicidin LL-37 induce IL-18 secretion through p38 and ERK MAPK activation in primary human keratinocytes
Sekiyama et al., J Med Invest 2005 : Inhibitors of caspase-1, reactive oxygen species and P38 MAPK prevented stress induced accumulation of plasma IL-18
Hewins et al., Kidney Int 2006 (Autoimmune Diseases...) : Furthermore, TNFalpha and IL-18 phosphorylated neutrophil p38 mitogen activated protein kinase ( MAPK ), but IL-18 mediated p38 MAPK phosphorylation was unaffected by anti-TNFalpha antibody
Kanda et al., Eur J Immunol 2007 : Inhibitors of PI3 K, p38 MAPK , and MEK suppressed IL-18 plus IFN-gamma induced CXCL9, CXCL10, and CXCL11 production and NF-kappaB, STAT1, and IRF-1 activities ... IL-18 induced phosphorylation of ERK and Akt, while IFN-gamma induced phosphorylation of p38 MAPK
Amin et al., Arthritis Rheum 2007 (Arthritis, Rheumatoid) : IL-18 induced phosphorylation of JNK, PKCdelta, p38 MAPK , and activating transcription factor 2 ( ATF-2 ) in RA ST fibroblasts in a time dependent manner, with JNK-2 being upstream of PKCdelta, ATF-2, and NFkappaB
Zabalgoitia et al., Free Radic Biol Med 2008 : IL-18 induced p38alpha MAPK activation, and suppressed p38beta isoform expression
Hamdi et al., Biochim Biophys Acta 2008 (MAP Kinase Signaling System) : As a functional consequence of this PLD2 dependent MAPK activation, interleukin-2 production evoked by PMA/ionomycin stimulation or CD3/CD28 engagement was enhanced in the two T-cell lines overexpressing PLD2
Munitz et al., Gastroenterology 2010 (Colitis...) : In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6, interleukin-1beta , and tumor necrosis factor alpha ) and activation of MAPK and NF-kappaB in Pirb-/- macrophages following bacterial activation
Glossop et al., J Tissue Eng Regen Med 2010 : In a previous gene expression study, we reported a potentially important role for mitogen activated protein kinase kinase kinase 8 ( MAP3K8 ) and interleukin-1ß ( IL-1B ) in MAPK signalling in MSCs exposed to fluid shear stress
Rasheed et al., Arthritis Res Ther 2010 (Osteoarthritis) : Pomegranate extract inhibits the interleukin-1ß induced activation of MKK-3, p38a-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes
Galbiati et al., Toxicol In Vitro 2011 (Dermatitis, Allergic Contact) : Regarding the signal transduction pathway, we could demonstrate using selective inhibitors a role for oxidative stress, NF-?B and p38 MAPK activation in PPD induced IL-18 production
Dauphinee et al., Am J Physiol Heart Circ Physiol 2011 : We find that Ga ( i/o ) -mediated activation of the MAPK is independent of the canonical MyD88, interleukin-1 receptor associated kinase, and tumor necrosis factor receptor associated factor 6 signaling cascade in LPS stimulated cells
Tormos et al., Hepatology 2013 (Chronic Disease...) : p38a mitogen activated protein kinases ( MAPK ) may be essential in the up-regulation of proinflammatory cytokines and can be activated by transforming growth factor ß, tumor necrosis factor-a, interleukin-1ß , and oxidative stress