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AKT1 — IL18
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Chandrasekar et al., J Biol Chem 2005
(Hypertrophy...) :
IL-18 induced
Akt phosphorylation and stimulated its activity, effects that were abolished by Akt inhibitor or knockdown
Chandrasekar et al., Biochem Biophys Res Commun 2006
:
Our results demonstrate that
IL-18 reduced
phospho-Akt and bcl-2 levels, stimulated NF-kappaB activation, and induced PTEN-promoter-reporter activity, mRNA expression, and protein levels in HCMEC
Yoo et al., J Immunol 2005
:
Instead,
IL-18 activated the
PI3K/Akt and MEK/ERK1/2 pathways
Kanda et al., Eur J Immunol 2007
:
IL-18 induced phosphorylation of ERK and
Akt , while IFN-gamma induced phosphorylation of p38 MAPK
Tranter et al., Free Radic Biol Med 2008
(Inflammation) :
This suppression of NF-kappaB reduces levels of PTEN which relieves
IL-18 mediated suppression of
Akt activity
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008
(Hyperglycemia) :
Resveratrol inhibits high glucose induced
PI3K/Akt/ERK dependent
interleukin-17 expression in primary mouse cardiac fibroblasts
Hosotani et al., J Dermatol 2008
:
Exogenous
IL-18 augmented phosphorylation of
Akt and activation of NF-kappaB
Kroeger et al., J Leukoc Biol 2009
:
In addition, basophil survival increased in the presence of
IL-18 or IL-33 as a
result of increased
Akt activation
Lin et al., Cytokine 2013
:
In vitro study using an aortic SMC line showed that
IL-18 up-regulated constitutive Cx43 expression and
potentiated tumor necrosis factor-a (TNF-a) triggered
Akt and MAPK signaling pathways