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IL17D — STAT3
Text-mined interactions from Literome
Hibbert et al., J Interferon Cytokine Res 2003
:
We report here that
IL-27 induces Stat1 and
Stat3 phosphorylation and activation in human and murine cell lines and primary human T cells
Takeda et al., Int Immunol 2005
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Our data suggest that WSX-1 plays a pivotal role in regulating T cell responsiveness to TCR stimulation and that the correct balance of
STAT1/STAT3 activation downstream of
IL-27R engagement is crucial for the physiological function of IL-27
Larousserie et al., J Immunol 2006
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In naive B cells,
IL-27 induced strong STAT1 and STAT3 phosphorylation, whereas it induced moderate STAT1 and low
STAT3 activation in memory B cells
Rückerl et al., Immunobiology 2006
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We previously demonstrated that
IL-27 induces
STAT-3 and is able to inhibit the production of pro-inflammatory cytokines in activated macrophages suggesting a novel feed-back mechanism by which IL-27 can modulate excessive inflammation
Yoshimura et al., J Immunol 2006
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In fully activated CD4+ T cells,
STAT3 was preferentially
activated by
IL-27 stimulation, whereas both STAT1 and 3 were activated by IL-27 in early activated CD4+ T cells
Owaki et al., J Immunol 2006
:
IL-27 , a novel member of the IL-6/IL-12 family,
activates both STAT1 and
STAT3 through its receptor, which consists of WSX-1 and gp130 subunits, resulting in positive and negative regulations of immune responses
Seita et al., Blood 2008
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Interleukin (IL)-27 , one of the most recently discovered IL-6 family cytokines,
activates both the signal transducer and activator of transcription ( STAT ) 1 and
STAT3 , and plays multiple roles in pro- and anti-inflammatory immune responses
Owaki et al., J Immunol 2008
:
IL-27 , a member of the IL-6/IL-12 family,
activates both STAT1 and
STAT3 through its receptor, which consists of WSX-1 and gp130 subunits, resulting in augmentation of Th1 differentiation and suppression of proinflammatory cytokine production ... These results suggest that
STAT3 is
activated through gp130 by
IL-27 and is indispensable to IL-27 mediated cell proliferation but not to IL-27 induced Th1 differentiation and suppression of proinflammatory cytokine production
Yoshimoto et al., J Immunol 2008
(Melanoma, Experimental) :
IL-27 is a member of the IL-6/IL-12 family and
activates both STAT1 and
STAT3 through its receptor, which consists of WSX-1 and gp130 ... Although WSX-1 expression was hardly detected in parental mouse melanoma B16F10 cells,
IL-27 activated STAT1 and
STAT3 and up-regulated MHC class I in B16F10 transfectants expressing wild-type WSX-1 ... Moreover, several human melanoma cells were revealed to express both IL-27 receptor subunits, and
activation of STAT1 and
STAT3 and growth inhibition by
IL-27 were detected
Frank et al., J Interferon Cytokine Res 2010
(Hepatitis C) :
IL-27 induces
STAT-1 and -3 in the cell line, and dose-dependently inhibited HCV
Batten et al., J Exp Med 2010
(Lupus Erythematosus, Systemic) :
IL-27 signaling to T cells results in the production of IL-21, a known autocrine factor for the maintenance of T ( FH ) cells, in a
STAT3 dependent manner
Schneider et al., Eur J Immunol 2011
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IL-27 induced rapid STAT1 and
STAT3 signaling, enhanced STAT1 protein levels, and induced SOCS1 and SOCS3 expression in a STAT1 dependent manner by human CD8 ( + ) T cells
Kamiya et al., Immunol Lett 2011
:
IL-27 , a member of the IL-6/IL-12 family cytokines,
activates STAT1 and
STAT3 , promotes early helper T ( Th ) 1 differentiation and generation of IL-10 producing type 1 regulatory T ( Tr1 ) cells, and suppresses the production of inflammatory cytokines and inhibits Th2 differentiation
Charlot-Rabiega et al., J Biol Chem 2011
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In B cells, this differential response is associated with similar levels of IL-27 receptor chains, IL-27Ra and gp130, in both subsets and stronger STAT1 and
STAT3 activation by
IL-27 in naive B cells
Diegelmann et al., J Biol Chem 2012
(Colitis...) :
IL-27 activates ERK and p38 MAPKs as well as Akt, STAT1,
STAT3 , and STAT6 in IEC
Nielsen et al., Microcirculation 2013
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Stimulation of lymphatic endothelial cell cultures with
IL-27 induced JAK dependent phosphorylation of STAT1 and
STAT3 and inhibited lymphatic endothelial cell proliferation and migration