Gene interactions and pathways from curated databases and text-mining

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IL17A — MAPK3

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Kawaguchi et al., J Allergy Clin Immunol 2001 (MAP Kinase Signaling System) : In addition, IL-17 induced activation of extracellular signal regulated kinase 1/2 but not of p38 or JNK kinases
Shimada et al., J Immunol 2002 : Furthermore, IL-17, IL-1beta, and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs, and specific MAPK inhibitors ( SB203580, PD98059, and U0216 ) significantly reduced IL-17- , IL-1beta-, or TNF-alpha induced IL-6 secretion, indicating the role of MAPKs in the induction of IL-6
Hsieh et al., Cytokine 2002 (MAP Kinase Signaling System) : Further, IL-17 induced the phosphorylation of src kinase and mitogen activated protein ( MAP ) kinase
Bamba et al., J Gastroenterol 2003 : A c-Jun/activating protein-1 (AP-1) inhibitor, curcumin, reduced the IL-17- , IL-1beta-, and TNF-alpha induced MMP-3 mRNA expression, and mitogen activated protein ( MAP ) kinase inhibitors ( U0126, PD098059, and SB203580 ) also blocked MMP-3 secretion
Kim et al., Arthritis Res Ther 2005 (Arthritis, Rheumatoid...) : However, inhibition of activator protein-1 and extracellular signal regulated kinase 1/2 did not affect IL-17 production
Wuyts et al., J Heart Lung Transplant 2005 : Western blotting clearly demonstrated that p38 MAPK , JNK and p42/p44 ERK were activated by IL-17 in HASMC ... We found that IL-17 induces activation of p38MAPK , JNK and p42/p44ERK in HASMC
Ning et al., Am J Physiol Lung Cell Mol Physiol 2005 (MAP Kinase Signaling System) : CO exposure selectively attenuated IL-17 induced ERK1/ERK2 MAPK activation without significantly affecting either JNK or p38 MAPK activation
Kanda et al., J Allergy Clin Immunol 2005 : IL-17 alone or synergistically with TNF-alpha induced dual phosphorylation of p38 MAPK and ERK
Rahman et al., J Immunol 2006 (Asthma...) : In addition, IL-17A mediated rapid phosphorylation of MAPK ( p38, JNK, and p42/44 ERK ) and STAT-3 but not STAT-6 or STAT-5 in ASM cells
Zhou et al., Cytokine 2007 (MAP Kinase Signaling System...) : IL-17A significantly induced activation of all three MAPK ( ERK, p38 and JNK ) and downstream transcription factors AP-1 and p65 NFkappaB
Patel et al., J Biol Chem 2007 : IL-17 stimulated p38 MAPK and ERK1/2 activation, and SB203580 and PD98059 blunted IL-17 mediated NF-kappaB and C/EBP activation and CRP transcription
Cortez et al., Am J Physiol Heart Circ Physiol 2007 : IL-17 induced p38 MAPK and ERK1/2 activation, and inhibition by SB-203580 and PD-98059 blunted IL-17 mediated transcription factor activation and MMP-1 expression
Paradowska et al., Arch Immunol Ther Exp (Warsz) 2007 (Arthritis, Rheumatoid) : IL-17 binding to an IL-17 receptor expressed on epithelial, endothelial, and fibroblastic stromal cells triggers the activation of transcription factor NF-kappaB and mitogen activated protein kinase ( p-38 ), which in turn results in the secretion of IL-1, TNF-alpha, IL-6, IL-8, or prostaglandin E2
Cheung et al., J Immunol 2008 (Inflammation) : Further investigations showed that IL-17A , IL-17F, and IL-23 differentially activated the ERK, p38 MAPK , and NF-kappaB pathways
Brereton et al., J Immunol 2009 (Autoimmune Diseases) : Inhibition of ERK MAPK suppresses IL-23- and IL-1-driven IL-17 production and attenuates autoimmune disease
Hosokawa et al., Cell Physiol Biochem 2009 : EGCG and ECG prevented IL-17A induced phosphorylation of p38 MAPK and ERK in HGFs
Iyoda et al., American journal of physiology. Renal physiology 2010 : Additionally, we observed that IL-17A and IL-17F induced MAPK ( p38 MAPK, ERK1/2, and JNK ) activation and that pharmacological inhibitors of p38 MAPK ( SB203580 ) and ERK1/2 ( U0126 ), but not JNK ( SP600125 ), blocked the IL-17A/IL-17F mediated MCP-1 and MIP-2 release
Gislette et al., TheScientificWorldJournal 2010 (Neoplasms...) : IL-17 could activate Src/PI3K, MAPK , Stat3, and PKC, resulting in carcinogenesis
Kim et al., Naunyn Schmiedebergs Arch Pharmacol 2011 : The IL-17 stimulated ERK 1/2, p38, and JNK MAPK activities and GSPE decreased IL-17 stimulated ERK 1/2, p38, and JNK MAPK activities ... The IL-17 stimulated ERK 1/2 , p38, and JNK MAPK activities and GSPE decreased IL-17 stimulated ERK 1/2, p38, and JNK MAPK activities
Noubade et al., Blood 2011 (Chronic Disease...) : Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis
Lai et al., Int J Gynecol Cancer 2011 (Genital Neoplasms, Female...) : IL-17 stimulation also activated phosphorylation of I?Ba and extracellular signal regulated kinase 1/2 in a time dependent manner
Valente et al., Cell Signal 2012 (Fibrosis...) : IL-17A mediated p38 MAPK and ERK1/2 activation is inhibited by MKP-1 overexpression, but prolonged by MKP-1 knockdown
Chen et al., Molecular vision 2011 : Inhibition of p38MAPK , phosphoinositide 3-kinase (PI3K)-Akt and nuclear factor-kappaB ( NF-?B ), with the inhibitors SB203580, LY294002 and pyrrolydine dithiocarbamate ( PDTC ) respectively, reduced IL-17 ( 100 ng/ml ) mediated production of CXCL8, CCL2, and IL-6 in a concentration dependent manner
Zhang et al., World J Gastroenterol 2012 (Inflammation...) : IL-17A induced rapid phosphorylation of p38 MAPK and ERK1/2 after 5 min exposure, and showed the strongest levels of phosphorylation of p38 MAPK and ERK1/2 at 15 min in IL-17A treated HSCs. IL-6 mRNA expression induced by IL-17A ( 100 ng/mL ) for 3 h exposure was inhibited by preincubation with specific inhibitors of p38 MAPK ( SB-203580 ) and ERK1/2 ( PD-98059 ) compared to groups without inhibitors preincubation ( 1.67 ± 0.24, 2.01 ± 0.10 vs 4.08 ± 0.59, P < 0.01 )