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AKT1 — IL13

Text-mined interactions from Literome

Wright et al., J Biol Chem 1999 : IL-13 also stimulates activation of the major PI 3-kinase effector, protein kinase B
Zhou et al., Am J Physiol Cell Physiol 2005 : Although IL-13 induced activation of PI3K-Akt , the activation did not contribute to the synergy observed with TGF-beta1 plus IL-13 in TIMP-1 expression and in fact may dampen it
Fujitsu et al., Invest Ophthalmol Vis Sci 2005 : Both IL-4 and IL-13 induced the phosphorylation of Akt and increased the kinase activity of this enzyme in a manner that was sensitive to the phosphatidylinositol 3-kinase inhibitors LY294002 or wortmannin
Grehan et al., J Immunol 2005 (MAP Kinase Signaling System...) : IL-4 and IL-13 induced rapid phosphorylation of Akt
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008 (Hyperglycemia) : Resveratrol inhibits high glucose induced PI3K/Akt/ERK dependent interleukin-17 expression in primary mouse cardiac fibroblasts
Wang et al., Am J Physiol Gastrointest Liver Physiol 2008 (Nematode Infections) : IL-13 stimulation activated PI3-kinase and AKT signal transduction in LS174T cells
Hosoyama et al., Clin Cancer Res 2011 (Cell Transformation, Neoplastic...) : IL-4 and IL-13 ligands accelerated tumor cell growth and activated STAT6, Akt , or MAPK signaling pathways in the human RMS cell lines, RD and Rh30, as well as in mouse primary ARMS cell cultures
Doroshow et al., Biochem Pharmacol 2012 : Exposure of HT-29 colon cancer cells, which express Nox1, to DPI and DTI confirmed their inhibitory effects on steady state ROS levels, and demonstrated decreased Stat, Erk1/2, and Akt signaling mediated by IL-4, IL-6, IL-13 , and IL-22, possibly due to a concomitant increase in tumor cell phosphatase activity