Gene interactions and pathways from curated databases and text-mining

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IL12A — STAT3

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Gollob et al., J Immunol 1999 : A specific inhibitor of p38 MAP kinase completely inhibits the serine phosphorylation of STAT1 and STAT3 induced by IL-12 and IL-2 and abrogates the functional synergy between IL-12 and IL-2 without affecting STAT tyrosine phosphorylation
Bright et al., J Immunol 1999 (Encephalomyelitis, Autoimmune, Experimental) : Inhibition of either Jak-2 or Tyk-2 leads to a decrease in the IL-12 induced tyrosine phosphorylation of Stat3 , but not of Stat4, protein
Hoentjen et al., Blood 2005 : Chromatin immunoprecipitation demonstrated enhanced NF-kappaB ( cRel, RelA ) binding to the IL-12p40 promoter in IL-10 ( -/- ) but not WT BMDCs. Interestingly, LPS induced STAT3 phosphorylation in WT but not IL-10 ( -/- ) BMDCs, a process blocked by IL-10 receptor blocking antibody
Muthian et al., J Clin Immunol 2004 (Disease Models, Animal...) : In vitro treatment of activated T cells with quercetin blocks IL-12 induced tyrosine phosphorylation of JAK2, TYK2, STAT3 , and STAT4, resulting in a decrease in IL-12 induced T cell proliferation and Th1 differentiation
Shirota et al., J Immunol 2004 (Autoimmune Diseases) : Findings indicate that these ODN inhibit IFN-gamma induced STAT1 phosphorylation and IL-12 induced STAT3 and STAT4 phosphorylation
Kusaba et al., J Biol Chem 2005 : IL-12 induced phosphorylation of Stat3 on Ser-727 was affected by rapamycin, which may be due to the effect of rapamycin on the IL-12 induced interaction between mammalian target of rapamycin (mTOR) and Stat3
Molenda et al., Mol Immunol 2006 : In keratinocytes, IL-12 activates STAT3 and STAT4 ; surprisingly, despite activating these transcription factors, the transcriptional effects of IL-12 did not rise above background levels
Muthian et al., J Neurosci Res 2006 (Disease Models, Animal...) : Treatment of activated T cells with 1,25 ( OH ) 2D3 also inhibited the IL-12 induced tyrosine phosphorylation of JAK2, TYK2, STAT3 , and STAT4 in association with a decrease in T cell proliferation in vitro
Li et al., J Immunol 2006 (Encephalomyelitis, Autoimmune, Experimental) : Indeed, in the present study we found that bone marrow derived DCs transduced with SOCS-3 significantly inhibited IL-12 induced activation of Stat4 and IL-23 induced activation of Stat3
Stewart et al., Cancer Cell 2009 (Neoplasms) : In this issue of Cancer Cell, Kortylewski et al. show that in the tumor microenvironment, STAT3 enhances the expression of the protumor cytokine IL-23 in macrophages but inhibits the antitumor cytokine IL-12 in dendritic cells
Kortylewski et al., Cancer Cell 2009 (Neoplasms) : Furthermore, Stat3 inhibits NF-kappaB/c-Rel dependent IL-12/p35 gene expression in tumor associated dendritic cells
Shanmugarajan et al., J Cell Biochem 2009 : Chromatin immunoprecipitation ( ChIP ) assay confirmed STAT-3 , but not STAT-1 binding to the OIP-1 gene promoter in response to IL-12 stimulation
Jacobson et al., J Exp Med 1995 : IL-12 selectively induced nuclear DNA binding complexes that contained Stat3 and Stat4, recently cloned members of the family of signal transducers and activators of transcription ( STATs )
Yu et al., J Immunol 1996 : In contrast to IL-2 and IFN-alpha, IL-12 induced strong tyrosine phosphorylation of STAT4 and variable weak phosphorylation of STAT3 ... However, supershift analyses using the c-fos promoter sis-inducible element probe showed that IL-12 activated STAT4, STAT1 alpha, and STAT3 , and induced complexes containing STAT4 only, STAT4 with STAT1 alpha, STAT3 with STAT1 alpha, or STAT1 alpha only in preactivated primary NK cells