Gene interactions and pathways from curated databases and text-mining

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IL11 — TPO

Text-mined interactions from Literome

Lu et al., J Hematother Stem Cell Res 2000 : In the presence of IL-11 , IL-3, SLF, and Tpo , CFU-MK derived from CB, mPBL, and BM was suppressed by tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta1 ( TGF-beta1 )
Ashizawa et al., Acta Endocrinol (Copenh) 1989 : Both interleukin 1 alpha and beta inhibited TSH induced thyroid peroxidase mRNA in a dose responsive manner ; 10 ( 3 ) U/1 interleukin 1 caused maximal suppression of TSH induced thyroid peroxidase mRNA level to nearly basal levels ... These results demonstrate that interleukin 1 directly inhibits TSH induced thyroid peroxidase gene expression and provide further evidence for a paracrine role of interleukin 1 as a local inhibitor of thyroid hormone synthesis