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EPO — IL11
Text-mined interactions from Literome
Fandrey et al., Ann N Y Acad Sci 1991
(Carcinoma, Hepatocellular...) :
A dose dependent decrease of up to 60 % in
Epo production was
induced by interleukin-1 beta,
interleukin-1 alpha, and tumor necrosis factor-alpha ( in that order of potency )
Ghinassi et al., Exp Hematol 2007
:
These results suggest that interleukin-3 and erythropoietin cooperate to establish the lineage-specific transcription factor milieu of erythroid cells
: interleukin-3 regulates mainly gene transcription and
erythropoietin consistently
increases mRNA and protein stability
Lifshitz et al., Haematologica 2010
:
The macrophages derived in-vitro from bone marrow cells expressed erythropoietin receptor transcripts, and in-vitro stimulation with
erythropoietin activated multiple signaling pathways, including signal transducer and activator of transcription ( STAT ) 1 and 5, mitogen activated protein kinase, phosphatidylinositol 3-kinase and nuclear factor kappa B. In-vitro erythropoietin treatment of these cells up-regulated their surface expression of CD11b, F4/80 and CD80, enhanced their phagocytic activity and nitric oxide secretion, and also
led to augmented
interleukin 12 secretion and decreased interleukin 10 secretion in response to lipopolysaccharide
Rodriguez et al., Exp Hematol 1995
:
We found that
IL-11 increased, in a dose dependent manner, the number of bursts in the
presence of
Epo in murine or human cells cultures