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IL10 — MAPK6

Text-mined interactions from Literome

Barcova et al., Pflugers Arch 1999 : Thus HIV-1 gp41 induced IL-10 up-regulation in monocytes may not involve NF-kappaB, MAPK , or PI 3-kinase activation, but rather may operate through activation of adenylate cyclase and pertussis-toxin-sensitive Gi/Go protein to effect p70 ( S6 ) -kinase activation
Song et al., J Surg Res 1999 (Sepsis) : Splenic immune suppression in sepsis : A role for IL-10 induced changes in P38 MAPK signaling
Song et al., J Surg Res 2000 (Bacterial Infections) : The results indicate that p38 MAPK inhibition with SB203580 suppressed the sepsis induced augmentation of interleukin-10 release while restoring the suppressed Th1 cytokine interleukin-2 release typically encountered following sepsis
Boussiotis et al., Blood 2001 (Blood Group Incompatibility...) : TGFbeta + IL-10-tolerant cells were incapable of phosphorylating TCR-zeta, or activating ZAP-70, Ras, and MAPK , similarly to T-cell tolerized by blockade of B7/CD28 and CD40/CD40L pathways
Reiling et al., J Immunol 2001 (MAP Kinase Signaling System) : Mycobacteria induced TNF-alpha and IL-10 formation by human macrophages is differentially regulated at the level of mitogen activated protein kinase activity
McDermott et al., J Biol Chem 2002 : Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1
Lim et al., J Immunol 2002 (MAP Kinase Signaling System) : Furthermore, SB202190, a specific inhibitor of p38 MAPK , inhibited LPS induced IL-10 production and reversed B7.2 down-regulation, suggesting that LPS induced B7.2 down-regulation may be mediated, at least in part, via regulation of IL-10 production by p38 MAPK
Kim et al., Neuroreport 2002 (Brain Injuries...) : IL-10 release was suppressed by an inhibitor of p38 MAPK , SB203580 but not by an inhibitor of ERK pathway, PD98059, whereas both SB203580 and PD98059 inhibited TNF-alpha release
Nagano et al., Int Immunol 2002 : Taken together, these results suggest that both ERK and p38 ( MAPK ) pathways are involved in LPS induced COX-2 expression and PGE ( 2 ) production in neutrophils, and IL-10 and IL-4 inhibit neutrophil prostanoid synthesis by down regulating the activation of p38 ( MAPK )
Khadaroo et al., Surgery 2002 (Reperfusion Injury...) : To discern whether this reduction in LPS stimulated MAPK activation after shock might contribute to reduced IL-10 , specific inhibitors were used ... Inhibition of p38 MAPK completely inhibited LPS induced IL-10 production, whereas blockade of extracellular regulated protein kinase pathway had no effect
Jiang et al., Shock 2002 (Inflammation...) : Inhibition of p38 MAPK with SB203580 inhibited the production of TNF-alpha and IL-10 by LPS stimulated KCs, whereas blockade of ERK1/2 with PD98059 could reduce TNF-alpha production, but did not affect IL-10 production
Yan et al., J Biol Chem 2002 : This model probiotic also inhibits activation of the pro-apoptotic p38/mitogen activated protein kinase by tumor necrosis factor, interleukin-1alpha , or gamma-interferon
Jee et al., J Invest Dermatol 2002 (Carcinoma, Basal Cell...) : Next, interleukin-6 stimulation elicited extracellular signal regulated kinase activation in basal cell carcinoma cells, and the mitogen activated protein kinase inhibitor, PD98059, could affect this response without affecting the interleukin-6-medi ated Mcl-1 upregulation
Guo et al., J Biol Chem 2003 (Inflammation) : Here we show unequivocally that the production of interleukin (IL)-1beta, IL-6, IL-10 , and tumor necrosis factor alpha (TNFalpha) requires p38 MAPK activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580
Inoue et al., J Immunol 2004 (MAP Kinase Signaling System) : IL-10 significantly inhibited CD40 induced activation of the ERK, p38 MAPK , and NF-kappaB pathways ; however, inhibition by IL-4 was limited to the ERK pathway in monocytes
Mathur et al., Nat Med 2004 (MAP Kinase Signaling System) : ERK-1/2 inhibition or IL-10 neutralization restores CD40 induced p38MAPK activation and parasite killing in macrophages and the BALB/c mouse, a susceptible host
Veiopoulou et al., Neuroimmunomodulation 2004 (MAP Kinase Signaling System) : Here we have examined the role of p38 MAPK on IL-2 and IL-10 production following activation of human CD4+ T cells or of the leukemic cell line Hut-78, with either plate bound anti-CD3 in the presence or absence of soluble anti-CD28 ( plCD3, plCD3/sCD28 ), or with cross linked anti-CD3 and anti-CD28 ( crsCD3+CD28 ), or with PMA plus ionomycin
Chaudhary et al., Toxicology 2004 : Pharmacological inhibition of phosphatidylinositol 3' kinase (PI3'K) by wortmannin and p38 mitogen activated protein kinase ( MAPK ) by SB203580 reveal that PI3'K mediates Be-specific p45 phosphorylation and IL6 release, whereas p38 MAPK regulates the release of IL6 and IL10 and the phosphorylation of p45 independent of metal-salt treatment
Wang et al., Am J Physiol Endocrinol Metab 2005 (Reperfusion Injury) : After I/R, myocardium was assessed for expression of TNF-alpha, IL-1beta, and IL-6 ( RT-PCR, ELISA ) ; IL-1alpha and IL-10 mRNA ( RT-PCR ) ; and activation of p38 MAPK ( Western blot )
Mason et al., Infect Immun 2004 : TRAF6 dependent mitogen activated protein kinase activation differentially regulates the production of interleukin-12 by macrophages in response to Toxoplasma gondii
Ji et al., Rheumatology (Oxford) 2005 : Also, inhibitors of extracellular signal regulated kinase ( ERKs ) ( PD98059 ), p38 MAPK ( mitogen activated protein kinase ) ( SB203580 ) and protein kinase C ( PKC ) ( GF109203X, calphostin C ) had no effect on 15d-PGJ2 mediated inhibition of IL-10 signalling
Rahimi et al., J Immunol 2005 : IL-10 induced the phosphorylation of PI3K and p42/44 ERK MAPK
Chi et al., Proc Natl Acad Sci U S A 2006 (Shock, Septic) : In response to TLR signals, MKP-1-deficient macrophages produced 5- to 10-fold higher IL-10 , which could be blocked by a p38 MAPK inhibitor ... Thus, p38 MAPK plays a critical role in mediating IL-10 synthesis in TLR signaling
Tran et al., Proc Natl Acad Sci U S A 2006 (Disease Models, Animal...) : By using a mouse model of multiple sclerosis, we found that the genetic loss of the MAPK , c-Jun N-terminal kinase 1 ( JNK1 ), enhances IL-10 production, rendering innate myeloid cells unresponsive to certain microbes and less capable of generating IL-17 producing, encephalitogenic T cells
Gee et al., J Immunol 2007 : IL-10 regulation by HIV-Tat in primary human monocytic cells : involvement of calmodulin/calmodulin dependent protein kinase activated p38 MAPK and Sp-1 and CREB-1 transcription factors ... Furthermore, Tat induced IL-10 expression was regulated by p38 MAPK- and CaMK II-activated CREB-1 as well as Sp-1 transcription factors
Horie et al., Microbiol Immunol 2007 (Burkitt Lymphoma) : We further analyzed molecular effects of p38 MAPK on IL-10 expression in Akata cells ... A specific inhibitor of p38 MAPK , SB203580, blocked simultaneously STAT3 DNA binding activity, and IL-10 mRNA expression, IL-10 production, and then the cell growth was inhibited
Li et al., Immunology 2007 : In conclusion, the coordinated activities of p38 MAPK and the transcription factors, Ets-1 and Sp-1, may play an important role in the HIV-1 Tat induced IL-10 transcription
Messmer et al., Mol Med 2006 (Opioid-Related Disorders) : The change in surface phenotype was paralleled by a p38 MAPK dependent decrease in IL-10 and increase in IL-12 secretion
Jarnicki et al., J Immunol 2008 (MAP Kinase Signaling System...) : We found that TLR ligands also promote the induction of IL-10 secreting regulatory T ( Treg ) cells through p38 MAPK induced IL-10 production by dendritic cells ( DC )
Hirata et al., Mol Immunol 2008 : Blocking either p38 MAPK or JNK1/2 pathway completely inhibited the synergistic enhancement of the IL-10 production by DCs upon upLPS and Pam3CSK4 stimulation
Hickey et al., J Leukoc Biol 2008 : CyaA enhanced LPS induced phosphorylation of p38 MAPK and ERK in DC, and inhibitors of p38 MAPK , MEK, or NF-kappaB suppressed IL-10 production in response to LPS and CyaA
Hamdi et al., Biochim Biophys Acta 2008 (MAP Kinase Signaling System) : As a functional consequence of this PLD2 dependent MAPK activation, interleukin-2 production evoked by PMA/ionomycin stimulation or CD3/CD28 engagement was enhanced in the two T-cell lines overexpressing PLD2
Kim et al., J Microbiol Biotechnol 2008 (MAP Kinase Signaling System) : These results suggest that the synergistic effect of PGA1 on LPS induced IL-10 expression is NF-kappaB dependent and mediated by mitogen activated protein ( MAP ) kinases , p38, and SAPK/ JNK signaling pathways, and also associated with the PPARgamma pathway
Krishnamurthy et al., Circ Res 2009 (Disease Models, Animal...) : These changes were associated with IL-10 mediated inhibition of p38 mitogen activated protein kinase activation and repression of the cytokine mRNA stabilizing protein HuR
Schaljo et al., J Immunol 2009 (Inflammation) : We found that IL-10 initiates a Stat3 dependent increase of TTP expression accompanied by a delayed decrease of p38 MAPK activity
Kamizato et al., J Gastroenterol 2009 (Colitis) : IL-10 also inhibited TNF-alpha stimulated induction of NOXO1 and p38 MAPK phosphorylation
Munitz et al., Gastroenterology 2010 (Colitis...) : In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6, interleukin-1beta , and tumor necrosis factor alpha ) and activation of MAPK and NF-kappaB in Pirb-/- macrophages following bacterial activation
Glossop et al., J Tissue Eng Regen Med 2010 : In a previous gene expression study, we reported a potentially important role for mitogen activated protein kinase kinase kinase 8 ( MAP3K8 ) and interleukin-1ß ( IL-1B ) in MAPK signalling in MSCs exposed to fluid shear stress
O'Leary et al., Am J Respir Cell Mol Biol 2011 (Granuloma...) : Our results suggest that IL-10 exerts its effects on this early macrophage response in a partly signal transducer and activator of transcription 3 ( STAT3 ) -dependent manner, and independent of mitogen activated protein kinase p38 ( MAPKp38 ) and extracellular regulated kinase 1/2 ( ERK1/2 ) activity
Rasheed et al., Arthritis Res Ther 2010 (Osteoarthritis) : Pomegranate extract inhibits the interleukin-1ß induced activation of MKK-3, p38a-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes
Zhang et al., J Leukoc Biol 2011 (Inflammation...) : This production of IL-10 is mediated by CaMKIa dependent regulation of p38 MAPK activation
Dauphinee et al., Am J Physiol Heart Circ Physiol 2011 : We find that Ga ( i/o ) -mediated activation of the MAPK is independent of the canonical MyD88, interleukin-1 receptor associated kinase, and tumor necrosis factor receptor associated factor 6 signaling cascade in LPS stimulated cells
Koscsó et al., J Immunol 2012 (MAP Kinase Signaling System) : In addition, adenosine augmented IL-10 production by stimulating p38 MAPK
Bebien et al., PLoS Pathog 2012 (Streptococcal Infections) : The pore forming toxin ß hemolysin/cytolysin triggers p38 MAPK dependent IL-10 production in macrophages and inhibits innate immunity
Hou et al., Virology journal 2012 : Additionally, p38 MAPK and NF-?B pathways but not ERK1/2 MAPK were actually activated in PRRSV infected BMDMs as demonstrated by western blot analysis, suggesting that p38 MAPK and NF-?B pathways are involved in the induction of IL-10 by PRRSV infection
Song et al., Dev Comp Immunol 2013 (Porcine Reproductive and Respiratory Syndrome) : Furthermore, treatment with specific inhibitors or siRNA knockdown assays demonstrated that NF-?B and p38 MAPK ( mitogen activated protein kinase ) are required for PRRSV induced IL-10
Tapia-Abellán et al., Liver Int 2013 (Liver Cirrhosis) : The release of the pro-inflammatory cytokines IL-6 and TNF-a at baseline was more effectively reduced by the MAPK inhibitors, while the basal IL-10 anti-inflammatory cytokine secretion was only and strongly ( 90.3 % ) affected by the PI3K inhibitor
Tormos et al., Hepatology 2013 (Chronic Disease...) : p38a mitogen activated protein kinases ( MAPK ) may be essential in the up-regulation of proinflammatory cytokines and can be activated by transforming growth factor ß, tumor necrosis factor-a, interleukin-1ß , and oxidative stress
Yin et al., Eur J Cell Biol 2013 : This study investigated the effect of IL-10 on mitogen activated protein kinase ( MAPK ) activation, and apoptosis induced by oxidized low-density lipoprotein ( oxLDL ) in cultured human umbilical vein endothelial cells ( HUVEC ) ... The results demonstrated that IL-10 significantly blocked the phosphorylation of p38 MAPK and c-Jun N-terminal kinase (JNK) and apoptosis induced by oxLDL
Foey et al., J Immunol 1998 : The results in this paper indicate that inhibition of p38 MAPK potently inhibited the production of IL-10 , IL-1beta, and TNF-alpha, whereas blockade of the p42/44 MAPK pathway, while partially inhibiting TNF-alpha and IL-1beta production, had no effect on monocyte secretion of IL-10