Gene interactions and pathways from curated databases and text-mining

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EPO — IL10

Text-mined interactions from Literome

Fandrey et al., Ann N Y Acad Sci 1991 (Carcinoma, Hepatocellular...) : A dose dependent decrease of up to 60 % in Epo production was induced by interleukin-1 beta, interleukin-1 alpha, and tumor necrosis factor-alpha ( in that order of potency )
Ghinassi et al., Exp Hematol 2007 : These results suggest that interleukin-3 and erythropoietin cooperate to establish the lineage-specific transcription factor milieu of erythroid cells : interleukin-3 regulates mainly gene transcription and erythropoietin consistently increases mRNA and protein stability
Strunk et al., Acta Paediatr 2008 : Furthermore, Epo significantly inhibits the synthesis of IL-4, IL-5 and IL-10 in adults
Lifshitz et al., Haematologica 2010 : The macrophages derived in-vitro from bone marrow cells expressed erythropoietin receptor transcripts, and in-vitro stimulation with erythropoietin activated multiple signaling pathways, including signal transducer and activator of transcription ( STAT ) 1 and 5, mitogen activated protein kinase, phosphatidylinositol 3-kinase and nuclear factor kappa B. In-vitro erythropoietin treatment of these cells up-regulated their surface expression of CD11b, F4/80 and CD80, enhanced their phagocytic activity and nitric oxide secretion, and also led to augmented interleukin 12 secretion and decreased interleukin 10 secretion in response to lipopolysaccharide