Gene interactions and pathways from curated databases and text-mining

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CASP5 — IL10

Text-mined interactions from Literome

Rojas et al., J Immunol 1999 : In contrast, anti-IL-10 increased caspase 1 activation, p53 expression, and apoptosis, although there was no increment in NO- production
Bachis et al., J Neurosci 2001 : IL-10 blocked both the glutamate mediated induction of caspase-3 as well as NF-kappaB DNA binding activity, suggesting that the neuroprotective properties of IL-10 may rely on its ability to block the activity of proapoptotic proteins
Guo et al., Blood 2003 : In the present study we confirm that Fas signaling induces both phenotypic and functional maturation of murine DCs, and we demonstrate that phenotypic maturation is associated with phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2, activation of caspase-1 , and secretion of interleukin-beta ( IL-1beta )
Kokura et al., Cancer Lett 2005 (Adenocarcinoma...) : IL-10 plasmid induced cancer cell apoptosis linked to the down-regulation of antiapoptotic proteins, and the activation of caspase-3
Wang et al., Ann Thorac Surg 2005 (Reperfusion Injury) : Myocardial tissue was then assessed for products of p38 MAPK activation, expression of tumor necrosis factor, interleukin-1beta and interleukin-6, and activation of caspase-1, caspase-3 and caspase-11
Tschoeke et al., Scand J Immunol 2008 (Disease Models, Animal...) : Thus, local thymic expression of IL-10 not only improves outcome but also reduces local tissue apoptosis and caspase-3 activity, and appears to attenuate the systemic proinflammatory cytokine response
Shushanov et al., Bull Exp Biol Med 2010 : Insulin-like growth factor-1 and insulin inhibit caspase-3/7 activation initiated by interleukin-1ß in the rat eye retinal neurons
Liao et al., Inflamm Res 2013 : Lipopolysaccharide/adenosine triphosphate mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1 mediated interleukin-1ß secretion