Mizukami et al., Mol Cell Biol 2002
(MAP Kinase Signaling System) :
In the interleukin-1 signaling pathway, TAK1 MAPK kinase kinase ( MAPKKK ) mediates MAPK and IKK activation via interaction with TRAF6, and TAB2 acts as an adapter linking TAK1 and TRAF6
de Alvaro et al., J Biol Chem 2004
(Insulin Resistance) :
Moreover, TNF-alpha produced inhibitor kappaB kinase (IKK)-beta activation and inhibitor kappaB-beta and -alpha degradation in a p38 MAPK dependent manner, and treatment with salicylate ( an inhibitor of IKK ) completely restored insulin signaling
Lee et al., J Mol Med (Berl) 2009
:
These results suggest that p38 MAPK may lead to the activation of IKK and NF-kappaB signaling, resulting in enhanced DC maturation and CXCL2 expression in response to C. difficile toxin A stimulation
Slomiany et al., Inflammopharmacology 2013
:
Induction in gastric mucosal prostaglandin and nitric oxide by Helicobacter pylori is dependent on MAPK/ERK mediated activation of IKK-ß and cPLA2 : modulatory effect of ghrelin