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AKT1 — IKBKE
Text-mined interactions from Literome
Xie et al., Proc Natl Acad Sci U S A 2011
(Cell Transformation, Neoplastic) :
IkappaB kinase epsilon and TANK binding kinase 1
activate AKT by direct phosphorylation
Guo et al., J Biol Chem 2011
(Breast Neoplasms...) :
Here, we report that
IKBKE ( also known as IKKe and IKKi )
activates Akt through a PI3K independent pathway ...
IKBKE activation of
Akt was not affected by inhibition of PI3K, knockdown of PDK1 or mTORC2 complex ... These findings indicate that
IKBKE is an Akt-Thr308 and -Ser473 kinase and directly
activates Akt independent of PI3K, PDK1, and mTORC2 as well as PH domain ... Our data also suggest that Akt inhibitors targeting the PH domain have no effect on the tumors in which hyperactive
Akt resulted from elevated
IKBKE
Guo et al., PloS one 2013
:
Previous studies have shown that
IKBKE directly
activates Akt and that Akt inhibits FOXO3a by phosphorylation of Ser32, Ser253 and Ser315