Gene interactions and pathways from curated databases and text-mining

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AKT1 — IKBKE

Text-mined interactions from Literome

Xie et al., Proc Natl Acad Sci U S A 2011 (Cell Transformation, Neoplastic) : IkappaB kinase epsilon and TANK binding kinase 1 activate AKT by direct phosphorylation
Guo et al., J Biol Chem 2011 (Breast Neoplasms...) : Here, we report that IKBKE ( also known as IKKe and IKKi ) activates Akt through a PI3K independent pathway ... IKBKE activation of Akt was not affected by inhibition of PI3K, knockdown of PDK1 or mTORC2 complex ... These findings indicate that IKBKE is an Akt-Thr308 and -Ser473 kinase and directly activates Akt independent of PI3K, PDK1, and mTORC2 as well as PH domain ... Our data also suggest that Akt inhibitors targeting the PH domain have no effect on the tumors in which hyperactive Akt resulted from elevated IKBKE
Guo et al., PloS one 2013 : Previous studies have shown that IKBKE directly activates Akt and that Akt inhibits FOXO3a by phosphorylation of Ser32, Ser253 and Ser315