Gene interactions and pathways from curated databases and text-mining

◀ Back to IGF1

IGF1 — IGFBP4

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Spicer et al., Domest Anim Endocrinol 1999 : In a third series of experiments, IGFBP-3 inhibited 125I-IGF-I binding to granulosa cells
Henemyre et al., Mol Reprod Dev 1999 : These results suggest that uterine IGFBP-4 expression may not be dependent on uterine IGF-I expression
Fottner et al., Horm Metab Res 1999 : In the present study, we therefore characterized the IGFBPs secreted by bovine adrenocortical cells in primary culture, and investigated the effect of corticotropin ( ACTH ) and recombinant human IGF-I and IGF-II on the regulation of IGFBP synthesis
Gustafsson et al., Am J Physiol 1999 : IGF-I stimulated gene expression of IGFBP-2 and IGFBP-4
Wilson et al., Eur J Endocrinol 1999 : Taken together, these data suggest that, in the monkey, IGFBP-3 is regulated by factors in addition to GH, and that IGF-I can affect its own bioavailability by increasing circulating concentrations of IGFBP-3
Giannini et al., Mol Cell Endocrinol 1999 : IGF-I increased IGFBP-3, IGFBP-2 and decreased IGFBP-4 , while TGF-beta1 decreased IGFBP-3 and apparently increased IGFBP-4
Schams et al., Domest Anim Endocrinol 1999 : Studies indicate that IGFBP expression and production in the developing follicle is dependent on both cell type and follicle size and is regulated by IGF-1 and gonadotropins
Pattison et al., Mol Cell Endocrinol 1999 (Breast Neoplasms) : By contrast, IGFBP-3 phosphorylation in T47D ( BP-3 ) cells was not affected by retinoic acid or IGF-I , but appeared slightly increased by estradiol
Huynh et al., Growth Horm IGF Res 2000 : We examined the effects of IGF-I on primary uterine myometrial cell proliferation, and on IGFBP-3 and IGFBP-4 gene expression ... In cell-free conditioned media IGF-I protected IGFBP-3 and enhanced IGFBP-4 proteolysis ... Northern blot analysis indicated that IGF-I increased IGFBP-4 mRNA accumulation by stabilizing the mRNA while IGFBP-3 gene expression was slightly decreased
Hodgson et al., Regul Pept 2000 : On the basis of such an experiment, performed at equilibrium, IGFBP should reduce the mitogenic activity of IGF-1
Dahlfors et al., Endocrinology 2000 : IGF-I , insulin, or angiotensin II did not affect IGF-I or IGFBP mRNA expression
Hayford et al., Growth Horm IGF Res 1998 : These findings suggest that cAMP, dexamethasone and IGF-I regulate IGFBP production in human aorta smooth muscle cells via a complex interplay of changes in transcription, protease activation and dissociation of cell surface bound IGFBPs
Fottner et al., J Endocrinol 2001 : In the present study, we identified and characterized IGFBP synthesis in normal adult human adrenocortical cells in primary culture, and investigated the effect of ACTH and recombinant human IGF-I and -II on the regulation of IGFBP expression and secretion
Hayes et al., J Clin Endocrinol Metab 2001 (Hypogonadism) : During rhIGF-I treatment, im expression of IGF-I declined, and IGF binding protein-4 increased , similar to the changes during GnRHa alone
Zeeh et al., Eur J Gastroenterol Hepatol 2001 (Colitis) : Therefore, we investigated the expression of IGFBPs, collagen and collagenase activity in rat colitis and the effects of IGF-1 on IGFBP and collagen expression in rat colonic smooth muscle cells
Boldt et al., Biochem J 2001 : Pregnancy associated plasma protein-A ( PAPP-A ) has recently been found to cleave IGFBP-4 in an IGF dependent manner
Laursen et al., FEBS Lett 2001 : In the presence of IGF , IGFBP-4 and -5 are cleaved with similar rates by PAPP-A ... In the presence of IGF , IGFBP-4 and -5 are cleaved with similar rates by PAPP-A
Sprenger et al., J Endocrinol 2001 (Cell Transformation, Viral) : Thus, IGFBP-3 acts in an IGF dependent manner to inhibit cell growth of benign prostate epithelial cells
Kiepe et al., J Am Soc Nephrol 2001 (Kidney Failure, Chronic) : Studies on the mechanism by which IGFBP-4 and IGFBP-5 exert opposite effects on chondrocyte proliferation demonstrated that intact IGFBP-4 prevented the binding of ( 125 ) I-IGF-I to chondrocytes, whereas intact IGFBP-5 enhanced ligand binding and was able to bind specifically to the cell membrane
Bostedt et al., Exp Cell Res 2001 (Bone Neoplasms...) : We compared the growth rates, IGFBP production, IGF I binding characteristics, IGF 1R protein and mRNA levels, and the acute IGF I response ( stimulation of glycogen synthesis ) after pretreatment of the cells in serum-free medium with or without added IGF I or medium supplemented with 5 % fetal calf serum ( FCS )
Price et al., Exp Lung Res 2001 : PDGF-BB regulates IGF mediated IGFBP-4 proteolysis in fetal lung fibroblasts ... These studies demonstrate that PDGF-BB increases the accumulation of ICFBP-4 in fetal rat lung fibroblasts CM through increased production and by inhibiting IGF mediated IGFBP-4 proteolysis
Søe et al., Eur J Biochem 2002 : Cleavage of IGFBP-4 is dramatically enhanced by the addition of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by IGF , as previously established with human PAPP-A
Yamane et al., Int J Dev Biol 2002 : The exogenous IGF-I stimulated differentiation of tongue myoblasts and induced the expressions of endogenous IGFBP4 , 5, and 6, suggesting that these IGFBPs were involved in the regulation of tongue myoblast differentiation by the IGF-I
Green et al., Kidney Int 2003 (Acidosis...) : Acidosis increased the expression of IGF-I binding protein-4 ( IGFBP-4 , an inhibitor of IGF-I activity ), whereas coincubation with PTH during acidic conditions abrogated the up-regulation of IGFBP-4
Hsu et al., J Biol Chem 1992 : The fasting induced increase in IGFBP-30K is inhibited by IGF-I and by des-IGF-I and, to a lesser extent, by insulin ... Unlike cell associated IGFBP-30K, secretion of IGFBP was stimulated ( 6.8 +/- 0.5-fold, n = 2 ) by IGF-I , whereas IGFBP secretion was inhibited 54 % by insulin ... These results demonstrate coordinate regulation of IGFBP by serum starvation and IGF-I , such that at low concentrations of IGF-I, cell surface binding protein increases whereas binding protein secretion decreases
Mohan et al., Acta Endocrinol (Copenh) 1992 (Bone Neoplasms...) : In this study, we sought to determine by Western ligand blotting the effects of growth hormone, IGF-I and IGF-II on the production of IGFBP-3 and IGFBP-4 in TE89 human osteosarcoma cells and in untransformed normal human bone cells derived from rib
Sheikh et al., Biochem Biophys Res Commun 1992 (Breast Neoplasms) : The levels of IGFBP-4 and IGFBP-5 were increased in MCF-7 cells by estradiol and IGF-I , respectively, indicating that these BPs may contribute to the growth stimulatory response to these mitogens
Hassager et al., J Clin Endocrinol Metab 1992 : In addition, IGF-I markedly increased levels of the 29/32/34 kDa IGFBP triplet in U-2 cells, but had little or no effect in the other human and rat osteosarcoma cell lines ... In addition, IGF-I markedly increased levels of the 29/32/34 kDa IGFBP triplet in U-2 cells, but had little or no effect in the other human and rat osteosarcoma cell lines
Grimes et al., Endocrinology 1992 : IGF-I , IGF-II, and the IGF-I analogs, but not insulin, also induced production of an unidentified 30-kDa IGFBP not normally detectable in these cultures ... IGF-I, IGF-II , and the IGF-I analogs, but not insulin, also induced production of an unidentified 30-kDa IGFBP not normally detectable in these cultures
Martin et al., Endocrinology 1992 : In this study we report that exogenous and endogenous IGFBP-3 inhibit production of an IGF inducible IGFBP
Fowlkes et al., Endocrinology 1992 : The IGF dependent decrease in IGFBP-4 was prevented by coincubation of the media with serine protease inhibitors, EDTA, or 1,10-phenanthrolene, suggesting that IGFs may activate an IGFBP-4 specific metallo-serine protease present in fibroblast conditioned media ... The demonstration that IGF-I and IGF-II can promote directly the proteolytic degradation of IGFBP-4 into fragments that do not bind IGFs provides a novel mechanism by which the IGFs may increase their own availability and/or activity in biological fluids
Kühl et al., Glia 2003 : When added exogenously, IGFBP-6 reduced O2A cell survival in the absence of IGF-1 and inhibited IGF-1 stimulated survival in a partially IGF-1 dependent and partially IGF-1 independent fashion
McCusker et al., J Endocrinol 2004 : Soluble IGFBP-5 and IGFBP-4 depressed the binding of ( 125 ) I-IGF-I and ( 125 ) I-IGF-II to the IGF-1R, but did not affect binding of ( 125 ) I-R ( 3 ) -IGF-I
Tanaka et al., Int J Cancer 2004 (MAP Kinase Signaling System...) : IGF-I induced IGFBP-4 proteolysis by PAPP-A may enhance cell growth and invasion through IGF-I dependent Akt and ERK1/2 activation and subsequently upregulation of uPA
Sirotkin et al., J Reprod Dev 2003 : These observations demonstrate the involvement of IGF-I and OT in the control of ovarian follicular size and follicular cell proliferation, progestagen, estrogen, IGFBP-3 , inhibin A and B secretion and in cAMP/PKA- and MAPK/ERK1 dependent intracellular mechanisms
King et al., Invest Ophthalmol Vis Sci 2004 : IGFBP production by these cells is further increased by IGF-I and -II, growth factors known to be present and active in proliferative vitreoretinal disorders, suggesting that Müller cells represent a potential source of vitreous IGFBPs in disorders involving this cell type
Voge et al., Peptides 2004 : Ligand blotting revealed that both IGF-1 and -2 increased IGFBP-2 and -5 ( protein ) and had no effect on IGFBP-3 ( protein ), whereas IGF-1 ( but not IGF-2 ) increased IGFBP-4 ( protein ), suggesting IGFBP-2, -4, and -5 are post-transcriptionally regulated
Kiepe et al., Endocrinology 2005 : We therefore studied the effect of IGF-I on IGFBP synthesis and the involved intracellular signaling pathways in two cell culture models of rat growth plate chondrocytes
Fleming et al., J Endocrinol 2005 : In BME cells, IGFBP-6 protein levels were readily detectable under basal conditions and were increased by IGF-I ... IGF-I increased IGFBP-4 mRNA levels by 2-fold in both cell types ... In vitro immuno-neutralization experiments showed that blocking PAPP-A prevented the ability of IGF-I to stimulate IGFBP-4 proteolysis
Moon et al., Int J Cancer 2006 (Carcinoma, Non-Small-Cell Lung...) : However, under certain circumstances, IGFBP-3 can enhance the activity of IGF by protecting IGF from degradation
Thraikill et al., J Clin Invest 1990 : Cultured human decidual cells release three IGF-BPs with 24,000, 30,000, and 34,000 Mr. Using ligand blot analysis and an RIA for the 30,000-Mr form ( IGF-BP-1 ), we examined the effects of IGF-I ( 10-1,000 ng/ml ), insulin ( 10-10,000 ng/ml ), and relaxin ( 10-250 ng/ml ) on decidual cell IGF-BP release after 120 h of hormone exposure
LaTour et al., Mol Endocrinol 1990 (Osteosarcoma) : Previous work indicated that hIGFBP-4 is the predominant IGFBP expressed by human osteoblast-like cells, and that IGFBP-4 binds and inhibits the mitogenic activities of IGF-I and IGF-II
Cheung et al., Endocrinology 1991 (Neuroblastoma) : Purified IGFBP-4 inhibited the binding of [ 125I ] IGF-I by its receptor and blunted stimulation of [ 3H ] thymidine incorporation by IGF-I ... Purified IGFBP-4 inhibited the binding of [ 125I ] IGF-I by its receptor and blunted stimulation of [ 3H ] thymidine incorporation by IGF-I
Conover et al., J Clin Invest 1991 (Cell Transformation, Viral) : The IGF-I induced change in IGFBP levels was not a type I IGF receptor mediated effect on IGFBP synthesis because ( a ) high concentrations of insulin did not mimic IGF-I 's effect ; ( b ) IGF-II and IGF-I analogues having reduced affinity for the IGF-I receptor were equipotent with IGF-I in increasing medium IGFBPs ; ( c ) [ QAYL ] IGF-I, and IGF-I analogue having normal receptor affinity and decreased affinity for IGFBPs, had no effect ; and ( d ) alpha IR-3, a monoclonal antibody specific for the type I IGF receptor, did not block IGF-I stimulated increases in IGFBPs ... The IGF-I induced change in IGFBP levels was not a type I IGF receptor mediated effect on IGFBP synthesis because ( a ) high concentrations of insulin did not mimic IGF-I 's effect ; ( b ) IGF-II and IGF-I analogues having reduced affinity for the IGF-I receptor were equipotent with IGF-I in increasing medium IGFBPs ; ( c ) [ QAYL ] IGF-I, and IGF-I analogue having normal receptor affinity and decreased affinity for IGFBPs, had no effect ; and ( d ) alpha IR-3, a monoclonal antibody specific for the type I IGF receptor, did not block IGF-I stimulated increases in IGFBPs
Gourmelen et al., Acta Paediatr Scand Suppl 1991 (Dwarfism) : Subcutaneous injection of IGF-I, 40 micrograms/kg, provoked an increase in serum IGF-I levels to close to the lower limits of the normal range and a small increase in IGFBP-3, suggesting that IGF-I has a direct effect on the synthesis of this GH/IGF-I dependent IGFBP
Laursen et al., Mol Endocrinol 2007 : Furthermore, we find that PAPP-A mediated IGF dependent cleavage of IGFBP-4 is inhibited by IGFBP-5, which sequesters IGF from IGFBP-4, and that cleavage of both IGFBP-4 and -5 is required for the release of bioactive IGF
Chesik et al., Cytokine Growth Factor Rev 2007 (Central Nervous System Neoplasms...) : In particular, IGFBP-2 plays a dominant role in IGF regulation in the CNS and is upregulated in several pathological conditions, including MS
Durai et al., Colorectal Dis 2007 (Colorectal Neoplasms) : Its binding proteins ( IGFBP ) are involved in local regulation of IGF
Ryan et al., Br J Cancer 2009 (Adenocarcinoma...) : IGFBP4 inhibits IGF1 activity but cleavage by pregnancy associated plasma protein-A ( PAPP-A ) protease releases active IGF1
Martin et al., Endocrinology 1990 (Cell Transformation, Neoplastic) : These results indicate that IGF-I and IGF-II induce an IGFBP that is different from previously characterized human IGFBPs
Ekström et al., Hormone research in pædiatrics 2011 (Insulin Resistance...) : After 8 months without treatment, we examined the short- and long-term effects of IGF-I/BP-3-Tx and, subsequently, IGF-I-Tx on 12-hour overnight levels of IGF-I , GH, insulin, IGFBP-1, insulin sensitivity by hyperinsulinemic euglycemic clamp, body composition by dual-energy X-ray absorptiometry and linear growth
Ritvos et al., Endocrinology 1988 (Choriocarcinoma...) : 34 K IGF-BP inhibited the binding of [ 125I ] iodo- ( Thr59 ) IGF-I to JEG-3 monolayers in a concentration dependent manner by forming with the tracer a soluble complex that could not bind to the cell surface as demonstrated by competitive binding and cross linking experiments
McCusker et al., J Cell Physiol 1988 : IGF-I , although it interferes with the assay and thereby lowers the amount of detectable IGF-BP, stimulated the secretion of IGF-BP from all three cell types
Pekonen et al., J Clin Endocrinol Metab 1988 : Purified 34K IGF-BP as well as decidual cytosols inhibited [ 125I ] IGF-I binding to placental receptors ... Purified 34K IGF-BP as well as decidual cytosols inhibited [ 125I ] IGF-I binding to placental receptors
Carlsson-Skwirut et al., Biochim Biophys Acta 1989 : This biological activity of recombinant truncated IGF-1 was not affected by the IGF-BP at concentrations which abolished the biological activity of recombinant IGF-1
Pekonen et al., Fertil Steril 1989 (Obesity...) : The 34K IGF binding protein ( 34K IGF-BP ) has been shown to inhibit the binding of IGF-I to its receptor
Lee et al., Pediatr Res 1989 (Growth Disorders...) : IGF-BP25 has been shown to inhibit IGF mitogenic action in vitro
Chen et al., J Cell Physiol 1994 (Breast Neoplasms...) : Therefore, IGFBP-3 secreted by MCF-7 cells can enhance IGF-I stimulation of DNA synthesis, increase IGF-I binding to these cells, and prevent IGF-I induced desensitization of its own receptor, suggesting that IGFBP-3 plays a significant role in IGF-I mediated breast carcinoma proliferation
Irwin et al., Regul Pept 1993 : We have investigated the regulation by insulin, IGF-I , and IGF-II, of IGFBP secretion in human endometrial stromal cells decidualized in vitro, and examined the interrelationship between the induced changes in IGFBP levels and the biological responses of stromal cells to IGFs
Caroni et al., J Cell Biol 1994 (Paralysis) : In tissue culture experiments with sensory- and motoneurons we demonstrate that the neurite promoting activity of IGF1 is blocked by IGF-BP4 , and that a similar IGF-BP-sensitive activity is detected in muscle extracts from paralyzed, but not from control muscle
McCarthy et al., J Cell Physiol 1994 : By Western ligand blot analysis, 24 h treatment with PGE2 elevated the 24 and 38-47 kDa IGFBPs and to a lesser extent the 30/32 kDa complex, hGH elevated the 38-47 kDa IGFBPs, and IGF-I and IGF-II each increased the 30/32 kDa IGFBP complex
Iwashita et al., Horm Res 1994 : Similarly, IGFBP-1 inhibited 125I-IGF-I binding to granulosa cells
Boney et al., Endocrinology 1994 : The presence of a larger isoform of IGFBP-2 in a differentiation dependent manner and a potentially novel IGFBP in response to IGF-I suggests that these IGFBPs may be important in modulating IGF-I action in adipogenesis
Oguchi et al., Am J Physiol 1994 : IGF-I stimulated mainly IGF-BP-3 production, but epidermal growth factor (EGF) and transforming growth factor-alpha ( TGF-alpha ) stimulated predominantly IGF-BP-4 secretion
Durham et al., J Clin Endocrinol Metab 1995 : Our data indicate that elevated endogenous levels of IGF can activate IGFBP-4 proteolysis, because in hOB cultures lacking detectable IGFBP-4 protein 1 ) basal IGF messenger ribonucleic acid expression was increased ; 2 ) IGF-II peptide levels were elevated ; 3 ) IGF neutralizing antibodies added to hOB-CM attenuated the proteolysis of exogenous IGFBP-4 ; and 4 ) recombinant human IGFBP-4 was proteolyzed into 2 immunoreactive fragments of approximately 18 and 14 kilodaltons during cell-free incubations in these hOB-CM without the addition of exogenous IGF
Durham et al., Endocrinology 1995 (Osteosarcoma) : Transient cell transformation induced by incubating human osteoblasts transfected with a temperature-sensitive mutant of simian virus-40 T-antigen at the permissive temperature or by treating hOB cells with phorbol ester tumor promoters also resulted in inhibition of IGF dependent IGFBP-4 proteolysis
Conover et al., Endocrinology 1995 : These data demonstrate that IGF peptide and glucocorticoid individually modulate IGFBP expression and indicate that glucocorticoid has distinct effects on IGF regulation of IGFBP depending upon the particular IGFBP and the underlying mechanism of IGF regulation
Duclos et al., Growth Regul 1994 (Liver Neoplasms, Experimental) : This suggested that IGF binding to LMH was due mainly to membrane bound IGFBP rather than to type 1 IGF receptors
Grellier et al., Br J Haematol 1995 : Characterization of insulin-like growth factor binding proteins ( IGFBP ) and regulation of IGFBP-4 in bone marrow stromal cells
Näntö-Salonen et al., Endocrinology 1993 (Hypothyroidism...) : The effects on IGFBP-2 ontogeny, and IGFBP-4 expression in the mature animal, however, are either direct thyroid hormone effects, or mediated by some other route, independent of GH, IGFs, or IGF receptors
McFarland et al., Gen Comp Endocrinol 1993 : Equimolar levels of IGF-I or insulin stimulated IGFBP release, however, at levels lower than that induced by IGF-II
Conover et al., Endocrinology 1993 : In HFCM from cells treated with vehicle, GH, insulin, epidermal growth factor, steroid hormones, or forskolin, IGF-II induced the select loss of detectable IGFBP-4 during the assay ... Treatment of cells with actinomycin-D or cycloheximide could prevent a phorbol ester induced block of IGF dependent IGFBP-4 proteolysis
Myers et al., Endocrinology 1993 : In the present study, we observed that the IGF-I mediated decrease in IGFBP-4 accumulation could be explained by increased IGFBP-4 proteolysis
Benedict et al., J Gerontol 1994 : In control animals, a striking increase ( 143 % ) in the predominant 39-45 kDa serum IGFBP ( BP-3 ), with little change in serum IGF-I , accompanied the marked deceleration of growth which occurred between 2 and 8 months ; the levels of IGF-I and its BPs declined by 15 % and 34 %, respectively, later in life
Lee et al., J Clin Endocrinol Metab 1996 (Nephrotic Syndrome) : We speculate that low serum IGF-I and IGFBP-3 levels would be partially due to the increased urinary losses of serum IGF-IGFBP complexes, especially that of 150 kDa, and these changes may contribute to growth failure in persistent nephrotic syndrome
Chevalley et al., Eur J Endocrinol 1996 : In the present study of normal human osteoblast-like ( HOB ) cells, we tested the hypothesis that dexamethasone ( Dex ) inhibits IGF anabolic activity in bone by altering expression of IGF binding proteins ( IGFBPs ), particularly by decreasing expression of IGFBP-5 and IGFBP-3 ( which enhance IGF activity ) and increasing expression of IGFBP-4 ( which inhibits IGF actions )
Grellier et al., J Endocrinol 1996 : Since IGF-I may regulate IGFBP production, the effect of IGF-I on IGFBPs expressed by TC-1 cells was determined
Kummer et al., Endocrinology 1996 : The stimulatory effect of bFGF and IGF-I on IGFBP production was apparent after a 2- to 3-day exposure of the mesencephalic cultures to the peptides ... We propose that the up-regulation of IGFBP-4 by IGF-I and bFGF may serve to localize IGF-I to sites of action in the nervous system and thereby potentiate the neurotrophic actions of IGF-I
Hembree et al., J Anim Sci 1996 : Insulin-like growth factor binding proteins ( IGFBP ) may act locally as autocrine or paracrine regulators of insulin-like growth factor activity in specific tissues such as muscle
Arai et al., Endocrinology 1996 : In summary, IGFBP-2 binding to glycosaminoglycans is dependent upon binding of IGF-I and IGF-II to IGFBP-2
Chen et al., J Anim Sci 1996 : We examined the time course of insulin-like growth factor binding protein ( IGFBP ) secretion and hormonal regulation of IGFBP and IGF-I secretion in porcine stromal vascular ( S-V ) cultures
Glander et al., Hum Reprod 1996 : IGF-I is mainly controlled by concentrations of human growth hormone ( HGH ), influences cell proliferation and differentiation and its action is mediated by insulin-like growth factor binding proteins ( IGFBP ), placental protein 14 (PP14) and prostate-specific antigen (PSA)
Monaco et al., J Endocrinol 1997 (Body Weight) : The decrease in IGFBP-3 and increase in lower molecular weight IGFBP may have contributed to the reduction in serum IGF-I by increasing IGF-I clearance from the circulation
Morales et al., Arch Biochem Biophys 1997 : By contrast, IGF-1 ( 10 ng/ml ) increased IGF-BP by < 2-fold ( n = 4 ), and retinoic acid, at 1 x 10 ( -8 ) M was not effective ( n = 3 )
Oguchi et al., Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi 1997 : The effects of IGF-I and EGF on IGFBP secretion diminished with increasing cell differentiation
Gentilini et al., J Cell Physiol 1998 (Hepatitis, Viral, Human) : IGFBP-4 protein levels decreased in response to IGF-I ... IGF-I and TGF-beta differentially regulate IGFBP-3, IGFBP-4 , and IGFBP-5 expression, which, in turn, may modulate the in vitro and in vivo action of IGF-I
Giannini et al., Metabolism 1997 : In fact, ( 1 ) IGFBP mRNA levels were not modified after stimulation with 100 nmol/L IGF-I, ( 2 ) 100 nmol/L IGF plus an equimolar concentration of alpha IR3 did not affect IGFBP production, ( 3 ) Des ( 1-3 ) IGF-I had no effect on IGFBP modulation, whereas at 10 nmol/L it enhanced BREC thymidine cell incorporation, and ( 4 ) 100 nmol/L insulin, which at this concentration can cross-react with the IGF-I receptor, did not modify the IGFBP pattern
McCusker et al., J Cell Physiol 1998 : IGFBP secretion by L6 cells is stimulated by both insulin/IGF-I and cAMP dependent pathways, whereas IGFBP-5 secretion by BC3H-1 cells is stimulated only by the insulin/IGF pathway
Elmlinger et al., Eur J Endocrinol 1998 : Elevated insulin-like growth factor (IGF) binding protein ( IGFBP)-2 and IGFBP-4 expression of leukemic T-cells is affected by autocrine/paracrine IGF-II action but not by IGF type I receptor expression ... Through inhibition using JB1, a peptide inhibiting the IGF signal transduction by blocking the IGF-I-R, we demonstrated the involvement of the IGF-I-R in IGFBP-2 and -4 expression and leukemic cell growth ... Thus, although IGF-I-R mediates the autocrine/paracrine effects of the IGFs, IGF-I-R mRNA expression is most probably not involved in the differential IGFBP-2/IGFBP-4 expression in leukemic cells
Sunic et al., Endocrinology 1998 : The aim of this study was to investigate the effects of IGF-I and IL-1 on IGFBP production by ovine articular chondrocytes ( OAC ) and the roles of these IGFBPs in the regulation of proteoglycan synthesis
Duan et al., J Biol Chem 1998 : In this study, we examined the role of autocrine/paracrine secreted IGF-I in controlling the expression of IGFBP-4 and IGFBP-5 as well as the effects of these IGFBPs in modulating the cellular replication response to IGF-I
Cabrol et al., Arch Pediatr 1998 (Growth Disorders...) : Elevated IGFBP levels may contribute to a reduced IGF activity, especially in dialysed patients