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IGFBP3 — MAPK3
Text-mined interactions from Literome
Lee et al., Cancer Res 2002
(Carcinoma, Non-Small-Cell Lung...) :
To delineate the underlying mechanism, we examined the
effect of
IGFBP-3 on Akt/protein kinase B and glycogen synthase kinase-3beta, downstream mediators of the phosphatidylinositol 3-kinase pathway, and on mitogen activated protein kinase (
MAPK ), all three of which are activated by IGF mediated signaling pathways and have important roles in cell survival ...
IGFBP-3 overexpression
inhibited the phosphorylation of Akt and glycogen synthase kinase-3beta and the activity of
MAPK
Lee et al., J Natl Cancer Inst 2004
(Carcinoma, Non-Small-Cell Lung...) :
The specific
effects of
Ad-IGFBP 3 and SCH66336 on
mitogen activated protein kinase and Akt were assessed by using adenoviral vectors that express constitutively active MEK1 or constitutively active Akt
Kim et al., Blood 2011
(Carcinoma...) :
Antiangiogenic antitumor activities of
IGFBP-3 are
mediated by IGF independent suppression of
Erk1/2 activation and Egr-1 mediated transcriptional events
Imamura et al., PloS one 2012
(Disease Progression...) :
An increase in
IGFBP-3 , mediated by depletion of FOXA1,
inhibited phosphorylation of
MAPK and Akt, and increased expression of the cell cycle regulators p21 and p27