Gene interactions and pathways from curated databases and text-mining

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IGFBP3 — MAPK3

Text-mined interactions from Literome

Lee et al., Cancer Res 2002 (Carcinoma, Non-Small-Cell Lung...) : To delineate the underlying mechanism, we examined the effect of IGFBP-3 on Akt/protein kinase B and glycogen synthase kinase-3beta, downstream mediators of the phosphatidylinositol 3-kinase pathway, and on mitogen activated protein kinase ( MAPK ), all three of which are activated by IGF mediated signaling pathways and have important roles in cell survival ... IGFBP-3 overexpression inhibited the phosphorylation of Akt and glycogen synthase kinase-3beta and the activity of MAPK
Lee et al., J Natl Cancer Inst 2004 (Carcinoma, Non-Small-Cell Lung...) : The specific effects of Ad-IGFBP 3 and SCH66336 on mitogen activated protein kinase and Akt were assessed by using adenoviral vectors that express constitutively active MEK1 or constitutively active Akt
Kim et al., Blood 2011 (Carcinoma...) : Antiangiogenic antitumor activities of IGFBP-3 are mediated by IGF independent suppression of Erk1/2 activation and Egr-1 mediated transcriptional events
Imamura et al., PloS one 2012 (Disease Progression...) : An increase in IGFBP-3 , mediated by depletion of FOXA1, inhibited phosphorylation of MAPK and Akt, and increased expression of the cell cycle regulators p21 and p27