Kim et al., Cancer Res 2004
(Breast Neoplasms) :
Induction of IGFBP-3 using an ecdysone-inducible expression system inhibited DNA synthesis in an IGF-IGF receptor axis independent fashion and resulted in the subsequent induction of apoptosis and an increase in caspase activity
Dar et al., J Invest Dermatol 2010
(Melanoma...) :
IGFBP3 overexpression also resulted in cleavage of caspase 3 and reduced expression of phosphorylated AKT